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ATPase H+ transporting accessory protein 1

Summary

Gene Symbol

ATP6AP1

Aliases

16A
Ac45
CF2
ORF
VATPS1
X-associated protein 3
XAP-3
XAP3
vacuolar ATPase subunit S1

Organism

Homo sapiens (human)

External Links

NCBI Gene

537

HGNC

868

KEGG Gene ID

hsa:537

PubChem

537

Alliance of Genome Resources

HGNC:868

Annotation

Keyword

3D-structure
Congenital disorder of glycosylation
Cytoplasmic vesicle
Disease variant
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Hydrogen ion transport
Phosphoprotein
Reference proteome
Signal
Synapse
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A384MQW4
Q15904	Protein XAP-3 V-ATPase Ac45 subunit V-ATPase S1 accessory protein Vacuolar proton pump subunit S1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
intracellular iron ion homeostasis	IMP	28296633
endosome to plasma membrane protein transport	ISS
regulation of cellular pH	IBA
synaptic vesicle lumen acidification	IEA
endosomal lumen acidification	NAS	32001091

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

osteoclast development

bone cell development [inference]

osteoclast development

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

endosome to plasma membrane protein transport

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to increased oxygen levels

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

osteoclast development

bone cell development [inference]

osteoclast development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

osteoclast development

bone cell development [inference]

osteoclast development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

regulation of cellular pH

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

neuron cellular homeostasis [inference]

synaptic vesicle lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

regulation of cellular pH

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

regulation of cellular pH

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

regulation of cellular pH

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to increased oxygen levels [inference]

cellular response to increased oxygen levels

cellular response to oxygen levels [inference]

cellular response to increased oxygen levels

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to increased oxygen levels

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to increased oxygen levels

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

vesicle-mediated transport [inference]

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

intracellular transport [inference]

intracellular protein transport [inference]

endosome to plasma membrane protein transport

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

endosome to plasma membrane protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

endosome to plasma membrane protein transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

endosome to plasma membrane protein transport

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

synaptic vesicle lumen acidification

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

endosome to plasma membrane protein transport

endosomal transport [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling [inference]

endosome to plasma membrane protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

establishment of protein localization to membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

endosome to plasma membrane protein transport

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

regulation of biological quality [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

Displaying entries **1 - 5** of 12 in total

1

2

3

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GO Term	Evidence Code	PMID
synaptic vesicle membrane	IEA
membrane	IDA	33065002
endoplasmic reticulum-Golgi intermediate compartment membrane	IEA
endoplasmic reticulum membrane	IEA
plasma membrane	NAS	32001091

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

proton-transporting two-sector ATPase complex

proton-transporting V-type ATPase complex

catalytic complex [inference]

ATPase complex [inference]

proton-transporting two-sector ATPase complex

proton-transporting V-type ATPase complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

endoplasmic reticulum-Golgi intermediate compartment membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	29127204 32353859 32814053 33060197 33845483 34232536 34997207
small GTPase binding	ISS
ATPase activator activity	IBA
transporter activator activity	IEA