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cadherin, EGF LAG seven-pass G-type receptor 2

Summary

Gene Symbol

Celsr2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

53883

PubChem

53883

Alliance of Genome Resources

MGI:1858235

Annotation

Keyword

Alternative splicing
Calcium
Cell membrane
Developmental protein
Direct protein sequencing
Disulfide bond
EGF-like domain
G-protein coupled receptor
Glycoprotein
Hydroxylation
Laminin EGF-like domain
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9R0M0	Flamingo homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
cilium movement	IMP	20473291
regulation of DNA-templated transcription	IDA	12755329
regulation of transcription, DNA-templated	IDA	12755329
homophilic cell adhesion via plasma membrane adhesion molecules	IDA	15296717
G protein-coupled receptor signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

G protein-coupled receptor signaling pathway

cell motility [inference]

cell migration [inference]

neuron migration [inference]

motor neuron migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

neural plate anterior/posterior regionalization

neural plate regionalization [inference]

neural plate anterior/posterior regionalization

neural plate pattern specification [inference]

neural plate regionalization [inference]

neural plate anterior/posterior regionalization

secretion by tissue [inference]

cerebrospinal fluid secretion

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure development [inference]

system development [inference]

ventricular system development

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

cerebrospinal fluid secretion

secretion by tissue [inference]

cerebrospinal fluid secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

G protein-coupled receptor signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of cellular localization [inference]

regulation of protein localization

regulation of biological quality [inference]

regulation of body fluid levels [inference]

body fluid secretion [inference]

cerebrospinal fluid secretion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	16484285
plasma membrane	ISO	19474315
plasma membrane	IDA	16484285

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IEA
calcium ion binding	IEA
protein binding	IPI	23292348

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cadherin egf lag seven-pass g-type

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
calcium ion binding
cell surface receptor signaling pathway

Displaying 1 entry
InterPro
GPCR, family 2-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10908	hydrocephalus	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 71 in total

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Species	Gene ID	Orthologous MAtrix
Saimiri boliviensis boliviensis	101039302	SAIBB22167
Takifugu rubripes	101064350	TAKRU20741
Felis catus	101098318	FELCA21459
Gorilla gorilla gorilla	101134391	GORGO17836
Tursiops truncatus	101329292	TURTR07755
Octodon degus	101572291	OCTDE14434
Jaculus jaculus	101611111	JACJA10434
Mustela putorius furo	101686152	MUSPF05948
Ficedula albicollis	101809280	FICAL09183
Chrysemys picta bellii	101947566	CHRPI26339