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ATPase copper transporting beta

Summary

Gene Symbol

ATP7B

Organism

Homo sapiens (human)

External Links

NCBI Gene

540

PubChem

540

Alliance of Genome Resources

HGNC:870

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Copper transport
Cytoplasm
Disease variant
Endosome
Golgi apparatus
Magnesium
Metal-binding
Mitochondrion
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Ribosomal frameshifting
Translocase
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
B7ZLR4
B7ZLR3
P35670	Copper pump 2 Wilson disease-associated protein
E7ET55
A0A669KB88

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
viral translational frameshifting	IEA
establishment of localization in cell	IEA
lactation	IEA
protein maturation by copper ion transfer	IEA
copper ion transport	IDA IGI IMP	12572677 26004889 9837819

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein maturation by copper ion transfer

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein maturation by copper ion transfer

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein maturation by copper ion transfer

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein maturation by copper ion transfer

cellular process [inference]

maintenance of location in cell [inference]

sequestering of calcium ion

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

copper ion transmembrane transport [inference]

copper ion export

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

copper ion transmembrane transport [inference]

copper ion export

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

viral process [inference]

viral translational frameshifting

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

copper ion homeostasis [inference]

intracellular copper ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

intracellular zinc ion homeostasis

copper ion homeostasis [inference]

intracellular copper ion homeostasis

response to stimulus [inference]

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to copper ion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

copper ion transport

copper ion import

copper ion transmembrane transport [inference]

copper ion export

monoatomic cation transmembrane transport [inference]

copper ion transmembrane transport [inference]

copper ion export

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

copper ion transmembrane transport [inference]

copper ion export

xenobiotic transport [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

secretion [inference]

body fluid secretion [inference]

lactation

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

copper ion transmembrane transport [inference]

copper ion export

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

copper ion transmembrane transport [inference]

copper ion export

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

establishment of localization in cell

maintenance of location [inference]

maintenance of location in cell [inference]

sequestering of calcium ion

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

body fluid secretion [inference]

lactation

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cytoplasmic vesicle	IDA	16472602
membrane	HDA	19946888
Golgi apparatus	IDA
late endosome	IDA	15681833
plasma membrane	IBA TAS	8298641

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

trans-Golgi network membrane

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

basolateral plasma membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

late endosome

perinuclear region of cytoplasm

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GO Term	Evidence Code	PMID
protein binding	IPI	12968035 16554302 16676348 16884690 17919502
P-type monovalent copper transporter activity	IEA
copper ion transmembrane transporter activity	IDA	26004889
ATP hydrolysis activity	IEA
copper ion binding	IBA IDA	12029094 14709553

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

transition metal ion transmembrane transporter activity [inference]

copper ion transmembrane transporter activity

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

transition metal ion transmembrane transporter activity [inference]

copper ion transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

sulfur compound transmembrane transporter activity [inference]

P-type divalent copper transporter activity

salt transmembrane transporter activity [inference]

P-type divalent copper transporter activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atpase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
ATPase-coupled monoatomic cation transmembrane transporter activity
copper ion binding
metal ion binding
nucleotide binding

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InterPro
HAD superfamily
HAD-like superfamily
Heavy metal-associated domain superfamily
Heavy metal-associated domain, HMA
Heavy-metal-associated, conserved site
P-type ATPase, A domain superfamily
P-type ATPase, cytoplasmic domain N
P-type ATPase, haloacid dehalogenase domain
P-type ATPase, phosphorylation site
P-type ATPase, subfamily IB

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:0111272	occipital horn syndrome	Alliance of Genome Resources
DOID:12377	spinal muscular atrophy	Alliance of Genome Resources
DOID:1838	Menkes disease	Alliance of Genome Resources
DOID:2237	hepatitis	Alliance of Genome Resources
DOID:2697	renal adenoma	Alliance of Genome Resources
DOID:3459	breast carcinoma	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:686	liver carcinoma	Alliance of Genome Resources
DOID:893	Wilson disease	Alliance of Genome Resources
DOID:896	metal metabolism disorder	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	11979		MGI:103297	MOUSE58406
Rattus norvegicus	24218		RGD:2180	RATNO11346
Drosophila melanogaster	32142		FB:FBgn0030343
Caenorhabditis elegans	176770		WB:WBGene00000834
Ovis aries	443046			SHEEP02097
Pan troglodytes	452734	9598_0:0038dd		PANTR07822
Canis lupus familiaris	476903			CANLF08654
Bos taurus	518075			BOVIN03721
Danio rerio	556499		ZFIN:ZDB-GENE-061220-5
Macaca mulatta	713781			MACMU16989

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Annotation

OrthoDB (Group)

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Acknowledgements