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Rho guanine nucleotide exchange factor

Summary

Gene Symbol

Arhgef7

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

54126

PubChem

54126

Alliance of Genome Resources

MGI:1860493

Annotation

Keyword

3D-structure
Alternative initiation
Alternative splicing
Cell junction
Cell projection
Coiled coil
Cytoplasm
Guanine-nucleotide releasing factor
Neurogenesis
Phosphoprotein
Proteomics identification
Reference proteome
SH3 domain

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9ES28	Beta-Pix PAK-interacting exchange factor beta p85SPR
A0A0R4J0X8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 15 in total

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GO Term	Evidence Code	PMID
Rho protein signal transduction	ISO
positive regulation of growth hormone secretion	IMP	21828338
astrocyte cell migration	ISO
hematopoietic progenitor cell differentiation	IGI	24029230
nervous system development	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction

small GTPase mediated signal transduction

Ras protein signal transduction [inference]

Rho protein signal transduction

actin filament-based process [inference]

actin cytoskeleton organization [inference]

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

cell motility [inference]

cell migration [inference]

glial cell migration [inference]

astrocyte cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

presynaptic cytoskeleton organization [inference]

presynaptic actin cytoskeleton organization

postsynaptic cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

Golgi organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

lamellipodium assembly

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

small GTPase mediated signal transduction

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

negative regulation of microtubule nucleation

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

negative regulation of microtubule nucleation

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of cytoskeleton organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

negative regulation of microtubule nucleation

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

negative regulation of microtubule nucleation

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of supramolecular fiber organization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

negative regulation of microtubule nucleation

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of peptide hormone secretion [inference]

regulation of growth hormone secretion [inference]

positive regulation of growth hormone secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of growth hormone secretion

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

positive regulation of binding [inference]

positive regulation of protein binding

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of binding [inference]

regulation of protein binding [inference]

positive regulation of protein binding

positive regulation of binding [inference]

positive regulation of protein binding

Displaying entry **16 - 16** of 16 in total

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GO Term	Evidence Code	PMID
GABA-ergic synapse	ISO

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

spindle pole [inference]

mitotic spindle pole

cytoplasm

cell cortex

microtubule organizing center [inference]

centrosome

cytosol

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

GABA-ergic synapse

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

storage vacuole

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

storage vacuole

cell body [inference]

neuronal cell body

postsynapse

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10428811 12626503 15102471 16959763 18325335 19022416 20080968 21295525 21828338 24035453
small GTPase binding	ISO
guanyl-nucleotide exchange factor activity	IBA IDA ISO	21828338
protein kinase binding	IPI ISO	21048939
gamma-tubulin binding	ISO ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

gamma-tubulin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

GTPase binding [inference]

small GTPase binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

rho guanine nucleotide exchange factor 7

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
lamellipodium assembly

Displaying **all 10** entries
InterPro
Dbl homology (DH) domain superfamily
Dbl homology (DH) domain
Guanine-nucleotide dissociation stimulator, CDC24, conserved site
PH-like domain superfamily
Pleckstrin homology domain
Rho guanine nucleotide exchange factor 6/7, coiled-coil domain
Rho guanine nucleotide exchange factor 7, SH3 domain
RhoGEF 6/7, PH domain
SH3 domain
SH3-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:6713	cerebrovascular disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **105** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8874		HGNC:15607	HUMAN17664
Drosophila melanogaster	35306		FB:FBgn0015803
Rattus norvegicus	114559	10116_1:004a37	RGD:620624	RATNO11475
Pan troglodytes	452673			PANTR08101
Danio rerio	494081		ZFIN:ZDB-GENE-041212-49
Bos taurus	524352			BOVIN04137
Danio rerio	553493		ZFIN:ZDB-GENE-060322-11	DANRE44770
Macaca mulatta	695530			MACMU16826
Monodelphis domestica	100017126			MONDO31947
Ornithorhynchus anatinus	100084578			ORNAN13612

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements