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N-acetylneuraminate synthase

Summary

Gene Symbol

NANS

Organism

Homo sapiens (human)

External Links

NCBI Gene

54187

KEGG Gene ID

hsa:54187

PubChem

54187

Alliance of Genome Resources

HGNC:19237

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Disease variant
Dwarfism
Intellectual disability
Phosphoprotein
Reference proteome
Transferase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NR45	N-acetylneuraminate synthase N-acetylneuraminate-9-phosphate synthase N-acetylneuraminic acid phosphate synthase N-acetylneuraminic acid synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
CMP-N-acetylneuraminate biosynthetic process	NAS	10749855
glycosylation	IBA
carbohydrate biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

phosphorus metabolic process [inference]

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate biosynthetic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate biosynthetic process

carbohydrate derivative metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

phosphorus metabolic process [inference]

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol	TAS
cytoplasm	NAS	10749855
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
N-acylneuraminate cytidylyltransferase activity	NAS	10749855
N-acylneuraminate-9-phosphate synthase activity	IBA TAS
N-acetylneuraminate synthase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

cytidylyltransferase activity [inference]

N-acylneuraminate cytidylyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000095380

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K05304

Name

sialic acid synthase [EC:2.5.1.56 2.5.1.57 2.5.1.132]

References

Rhea

RHEA:13421

H₂O + an N-acyl-D-mannosamine 6-phosphate + phosphoenolpyruvate

phosphate + an N-acylneuraminate 9-phosphate

Enzyme

2.5.1.57

PMID

10873658

RHEA:19273

H₂O + N-acetyl-D-mannosamine + phosphoenolpyruvate

N-acetylneuraminate + phosphate

Enzyme

2.5.1.56

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **121** in total

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DO ID	Disease Name	Source
DOID:0050425	restless legs syndrome	DisGeNET
DOID:0050847	sleep apnea	DisGeNET
DOID:0050848	obstructive sleep apnea	DisGeNET DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0050908	myelodysplastic syndrome	DisGeNET
DOID:0060123	connective tissue benign neoplasm	DisGeNET
DOID:0060224	atrial fibrillation	DisGeNET
DOID:0060731	congenital central hypoventilation syndrome	DisGeNET
DOID:0060823	syndromic X-linked intellectual disability 94	DisGeNET
DOID:0080302	mixed sleep apnea	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 46 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000179	Thick lower lip vermilion
HP:0000248	Brachycephaly
HP:0000252	Microcephaly
HP:0000280	Coarse facial features
HP:0000286	Epicanthus
HP:0000294	Low anterior hairline
HP:0000414	Bulbous nose
HP:0000445	Wide nose
HP:0000470	Short neck

Displaying 1 entry
Disease ID	Disease Name
OMIM:610442	spondyloepimetaphyseal dysplasia, Genevieve type

PubChem Disease

MedGen Diseases

Spondyloepimetaphyseal dysplasia, Genevieve type

OMIM Phenotypes

SPONDYLOEPIMETAPHYSEAL DYSPLASIA, GENEVIEVE TYPE; SEMDG

KEGG Diseases

Spondyloepimetaphyseal dysplasia

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	41528	FB:FBgn0038045
Callorhinchus milii	103177631		CALMI13453
Callorhinchus milii	103177633		CALMI13454
Danio rerio	322780	ZFIN:ZDB-GENE-030131-1500	DANRE17112
Danio rerio	492779	ZFIN:ZDB-GENE-041114-125
Ictalurus punctatus	100528493		ICTPU23577
Electrophorus electricus	113568448		ELEEL49860
Salmo salar	100195066		SALSA24857
Salmo trutta	115191851		SALTR31477
Gadus morhua	115540714		GADMO41839

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements