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cytochrome p450 oxidoreductase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

5447

PubChem

5447

Alliance of Genome Resources

HGNC:9208

Annotation

Keyword

3D-structure
Acetylation
Congenital adrenal hyperplasia
Craniosynostosis
Direct protein sequencing
Disease variant
Endoplasmic reticulum
FAD
FMN
NADP
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A9L9PY49
P16435

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cellular organofluorine metabolic process	IDA	19448135
response to hormone	IBA
xenobiotic metabolic process	TAS
nitric oxide biosynthetic process	IBA
electron transport chain	IDA	10048323 2513880

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

reactive nitrogen species metabolic process [inference]

nitric oxide metabolic process [inference]

nitric oxide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain

xenobiotic metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular organohalogen metabolic process [inference]

cellular organofluorine metabolic process

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain

xenobiotic metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nitric oxide biosynthetic process

cellular organohalogen metabolic process [inference]

cellular organofluorine metabolic process

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone

response to chemical [inference]

response to organic substance [inference]

response to hormone

biological regulation [inference]

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

positive regulation of monooxygenase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	HDA	19946888
endoplasmic reticulum membrane	TAS
intracellular membrane-bounded organelle	IDA	9618440
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21081644 35271311
NADP binding	IEA
NADPH-hemoprotein reductase activity	IBA IDA TAS	10048323 19448135 2513880
FMN binding	IBA
flavin adenine dinucleotide binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [inference]

NADPH-hemoprotein reductase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

ribonucleotide binding [inference]

FMN binding

flavin adenine dinucleotide binding

ion binding [inference]

anion binding [inference]

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

ribonucleotide binding [inference]

FMN binding

flavin adenine dinucleotide binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

FMN binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

reductase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
FMN binding
flavin adenine dinucleotide binding
oxidoreductase activity

Displaying **all 7** entries
InterPro
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Flavoprotein pyridine nucleotide cytochrome reductase
NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
Oxidoreductase FAD/NAD(P)-binding
Riboflavin synthase-like beta-barrel
Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050462	Antley-Bixler syndrome with disordered steroidogenesis	Alliance of Genome Resources
DOID:0050811	congenital adrenal hyperplasia	Alliance of Genome Resources
DOID:0080925	cytochrome P450 oxidoreductase deficiency	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **111** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18984		MGI:97744	MOUSE46621
Rattus norvegicus	29441		RGD:68335	RATNO05461
Drosophila melanogaster	33883		FB:FBgn0015623
Caenorhabditis elegans	175710		WB:WBGene00001262
Danio rerio	327556		ZFIN:ZDB-GENE-030131-5767	DANRE08988
Xenopus laevis	379707		Xenbase:XB-GENE-951366
Pan troglodytes	463481	9598_0:001fef		PANTR40557
Canis lupus familiaris	489816			CANLF16157
Bos taurus	532512			BOVIN20772
Danio rerio	568202		ZFIN:ZDB-GENE-050809-121

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements