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ATR serine/threonine kinase
Summary
- Gene Symbol
-
- ATR
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Chromosome
- DNA repair
- DNA-binding
- Disease variant
- Dwarfism
- Intellectual disability
- Manganese
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- Serine/threonine-protein kinase
- Proteins
| UniProt | Protein Name |
|---|---|
| Q13535 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| interstrand cross-link repair | ||
| response to arsenic-containing substance | ||
| DNA damage checkpoint signaling | ||
| replication fork processing | ||
| establishment of RNA localization to telomere |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cell cycle [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| ATR-ATRIP complex | ||
| Golgi apparatus | ||
| chromosome, telomeric region | ||
| PML body | ||
| nucleoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| protein serine kinase activity | ||
| DNA binding | ||
| histone H2AXS139 kinase activity | ||
| MutSalpha complex binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- phosphatidylinositol 3
- Functional Category
-
- E: Amino acid transport and metabolism
- I: Lipid transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| transferase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050569 | Seckel syndrome | |
| DOID:0060060 | non-Hodgkin lymphoma | |
| DOID:0070007 | Seckel syndrome 1 | |
| DOID:0080202 | adenoid cystic carcinoma | |
| DOID:10652 | Alzheimer's disease | |
| DOID:12704 | ataxia telangiectasia | |
| DOID:1324 | lung cancer | |
| DOID:1380 | endometrial cancer | |
| DOID:1612 | breast cancer | |
| DOID:1793 | pancreatic cancer |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 32608 | FB:FBgn0004367 | |||
| 179352 | WB:WBGene00000226 | |||
| 245000 | MGI:108028 | MOUSE62386 | ||
| 398197 | Xenbase:XB-GENE-1012725 | |||
| 460745 | 9598_0:000fe8 | PANTR32360 | ||
| 567770 | ZFIN:ZDB-GENE-070912-458 | DANRE29334 | ||
| 685055 | RGD:1305796 | RATNO41864 | ||
| 714443 | MACMU29687 | |||
| 852433 | SGD:S000000340 | |||
| 100073649 | ORNAN11920 |
