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ADAMTS like 4

Summary

Gene Symbol

ADAMTSL4

Organism

Homo sapiens (human)

External Links

NCBI Gene

54507

PubChem

54507

Alliance of Genome Resources

HGNC:19706

JoGo

ADAMTSL4

TogoVar

ADAMTSL4

Annotation

Keyword

Alternative splicing
Apoptosis
Extracellular matrix
Glycoprotein
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7ZMJ3
Q6UY14	Thrombospondin repeat-containing protein 1
A0A669KBE7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
epithelial cell development	IEA
apoptotic process	IEA
extracellular matrix organization	IEA
positive regulation of apoptotic process	IDA	16364318
pigment cell development	IEA

GO Hierarchy

biological process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular developmental process [inference]

cell development [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

cellular developmental process [inference]

cell development [inference]

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
interstitial matrix	IEA
endoplasmic reticulum lumen	TAS
collagen-containing extracellular matrix	HDA	25037231 28327460

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

interstitial matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protease binding	IPI	16364318
protein binding	IPI	16189514 16364318 19060904 23088713 24722188 25416956 25910212 26871637 29758265 32296183 32814053
identical protein binding	IPI	32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

protease binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

thrombospondin

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 3** entries
Gene Ontology
extracellular matrix organization
metalloendopeptidase activity
proteolysis

Displaying **all 4** entries
InterPro
ADAMTS/ADAMTS-like, Spacer 1
PLAC
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111149	autosomal recessive isolated ectopia lentis 2	Alliance of Genome Resources
DOID:0111648	ectopia lentis with ectopia of pupil	Alliance of Genome Resources