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pseudouridine synthase 7

Summary

Gene Symbol

PUS7

Organism

Homo sapiens (human)

External Links

NCBI Gene

54517

PubChem

54517

Alliance of Genome Resources

HGNC:26033

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Disease variant
Dwarfism
Intellectual disability
Isomerase
Nucleus
Phosphoprotein
Reference proteome
mRNA splicing
tRNA processing

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q96PZ0
B3KRB2
B3KY42

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
pseudouridine synthesis	IBA
RNA splicing	IEA
mRNA pseudouridine synthesis	IDA IMP	28073919 31477916 35051350
tRNA pseudouridine synthesis	IDA	29628141 34718722
regulation of mesoderm development	IMP	29628141

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

RNA modification [inference]

pseudouridine synthesis

tRNA modification [inference]

tRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA processing

mRNA modification [inference]

mRNA pseudouridine synthesis

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA pseudouridine synthesis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of mesoderm development

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

Displaying 1 entry
GO Term	Evidence Code	PMID
nucleus	IBA IDA	29628141 35144859

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
enzyme binding	IPI	23382074
RNA binding	HDA	22658674 22681889
pseudouridine synthase activity	IBA IDA IMP	28073919 29628141 31477916 35051350

GO Hierarchy

molecular function

catalytic activity [inference]

isomerase activity [inference]

intramolecular transferase activity [inference]

pseudouridine synthase activity

binding [inference]

protein binding [inference]

enzyme binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

pseudouridine synthase

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 2** entries
Gene Ontology
isomerase activity
pseudouridine synthesis

Displaying **all 4** entries
InterPro
Pseudouridine synthase, TruD, catalytic domain
Pseudouridine synthase, TruD, insertion domain
Pseudouridine synthase, TruD
Pseudouridine synthase, catalytic domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0081265	intellectual developmental disorder with abnormal behavior, microcephaly, and short stature	Alliance of Genome Resources
DOID:1059	intellectual disability	Alliance of Genome Resources
DOID:10907	microcephaly	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	38969		FB:FBgn0035901
Mus musculus	78697		MGI:1925947	MOUSE45195
Caenorhabditis elegans	179436		WB:WBGene00007101
Rattus norvegicus	296751		RGD:1307054	RATNO29628
Danio rerio	402995		ZFIN:ZDB-GENE-060620-1	DANRE26812
Pan troglodytes	472481	9598_0:001fa2		PANTR41122
Xenopus tropicalis	549638		Xenbase:XB-GENE-5812368
Macaca mulatta	697463			MACMU32158
Xenopus laevis	734727		Xenbase:XB-GENE-5812471
Saccharomyces cerevisiae S288C	854417		SGD:S000005769

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements