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heparanase 2

Summary

Gene Symbol

Hpse2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

545291

PubChem

545291

Alliance of Genome Resources

MGI:2685814

Annotation

Keyword

Extracellular matrix
Glycoprotein
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
B2RY83

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cell population proliferation	IMP	25510506
positive regulation of cell population proliferation	IMP	25510506
extracellular matrix organization	IMP	25510506
extracellular matrix organization	IBA

GO Hierarchy

biological process

cellular process [inference]

cell population proliferation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

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GO Term	Evidence Code	PMID
extracellular region	IEA
extracellular space	IBA
membrane	IEA
extracellular matrix	ISO
extracellular matrix	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

Displaying **all 3** entries
GO Term	Evidence Code	PMID
hydrolase activity, acting on glycosyl bonds	IEA
heparan sulfate proteoglycan binding	ISO
heparan sulfate proteoglycan binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

binding [inference]

protein binding [inference]

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

carbohydrate derivative binding [inference]

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

heparan sulfate proteoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Heparanase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
hydrolase activity, acting on glycosyl bonds

Displaying **all 2** entries
InterPro
Glycoside hydrolase superfamily
Glycoside hydrolase, family 79

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050816	urofacial syndrome	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	10855	FB:FBgn0038611
Drosophila melanogaster	15442	FB:FBgn0038611
Homo sapiens	60495	Xenbase:XB-GENE-989584	HUMAN02456
Xenopus tropicalis	64537	Xenbase:XB-GENE-989584
Rattus norvegicus	368128		RATNO18611
Pan troglodytes	466176		PANTR01326
Xenopus tropicalis	545291	Xenbase:XB-GENE-989584
Macaca mulatta	708795		MACMU46771
Equus caballus	100070602		HORSE17307
Sus scrofa	100157983		PIGXX08304

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements