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pyruvate dehydrogenase phosphatase catalytic subunit 1

Summary

Gene Symbol

PDP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

54704

PubChem

54704

Alliance of Genome Resources

HGNC:9279

Annotation

Keyword

Acetylation
Alternative splicing
Calcium
Disease variant
Magnesium
Manganese
Metal-binding
Mitochondrion
Protein phosphatase
Reference proteome
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9P0J1	Protein phosphatase 2C Pyruvate dehydrogenase phosphatase catalytic subunit 1
Q6P1N1	Protein phosphatase 2C Pyruvate dehydrogenase phosphatase catalytic subunit 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
peptidyl-threonine dephosphorylation	IDA	20801214
signal transduction	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

cellular process [inference]

signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation [inference]

peptidyl-threonine dephosphorylation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

Displaying **all 3** entries
GO Term	Evidence Code	PMID
pyruvate dehydrogenase (lipoamide) phosphatase complex	NAS	6293549
mitochondrion	HTP IBA IDA NAS	19184109 34800366 6293549
mitochondrial matrix	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

phosphatase complex [inference]

protein serine/threonine phosphatase complex [inference]

pyruvate dehydrogenase (lipoamide) phosphatase complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 32296183
[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity
metal ion binding	IEA
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IBA IDA IEA	15554715
protein serine/threonine phosphatase activity	IDA	20801214

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

phosphatase regulator activity [inference]

protein phosphatase regulator activity [inference]

[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phosphatase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hydrolase activity
phosphoprotein phosphatase activity

Displaying **all 3** entries
InterPro
PPM-type phosphatase-like domain superfamily
PPM-type phosphatase-like domain
Protein phosphatase 2C

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3649	pyruvate decarboxylase deficiency	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	31683		FB:FBgn0029958
Rattus norvegicus	54705		RGD:620393	RATNO34872
Caenorhabditis elegans	172035		WB:WBGene00022832
Bos taurus	280891			BOVIN06188
Mus musculus	381511		MGI:2685870	MOUSE42645
Xenopus laevis	447514		Xenbase:XB-GENE-6253767
Pan troglodytes	472819	9598_0:00258d		PANTR42951
Canis lupus familiaris	477941			CANLF11797
Danio rerio	558728		ZFIN:ZDB-GENE-060810-70	DANRE11003
Macaca mulatta	699172			MACMU43420

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