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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
proprotein convertase subtilisin/kexin type 4
Summary
- Gene Symbol
-
- PCSK4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Cleavage on pair of basic residues
- Cytoplasmic vesicle
- Glycoprotein
- Reference proteome
- Serine protease
- Signal
- Transmembrane helix
- Zymogen
- Proteins
| UniProt | Protein Name |
|---|---|
| Q6UW60 |
|
| A0A140VJQ9 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| reproductive process | ||
| binding of sperm to zona pellucida | ||
| sperm capacitation | ||
| acrosome reaction | ||
| peptide hormone processing |
| GO Term | Evidence Code | PMID |
|---|---|---|
| acrosomal membrane | ||
| trans-Golgi network | ||
| Golgi membrane | ||
| acrosomal vesicle |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| serine-type endopeptidase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- FURIN
- Functional Category
-
- E: Amino acid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| hydrolase activity |
| peptide hormone processing |
| proteolysis |
| serine-type endopeptidase activity |
| serine-type peptidase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050861 | colorectal adenocarcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 18551 | MGI:97514 | MOUSE02745 | ||
| 47220 | FB:FBgn0004509 | |||
| 171085 | RGD:620325 | RATNO39394 | ||
| 173051 | WB:WBGene00002232 | |||
| 485083 | CANLF08094 | |||
| 497630 | Xenbase:XB-GENE-969617 | |||
| 508744 | BOVIN33401 | |||
| 707567 | MACMU19903 | |||
| 749996 | 9598_0:004a7b | |||
| 779814 | Xenbase:XB-GENE-969614 |
