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Guidelines

MIRAGE

CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase

Summary

Gene Symbol

CDKAL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

54901

PubChem

54901

Alliance of Genome Resources

HGNC:21050

Annotation

Keyword

4Fe-4S
Alternative splicing
Diabetes mellitus
Endoplasmic reticulum
Phosphoprotein
Reference proteome
S-adenosyl-L-methionine
Transferase
Transmembrane helix
tRNA processing

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5VV42	CDK5 regulatory subunit-associated protein 1-like 1 tRNA-t(6)A37 methylthiotransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
biological_process	ND
tRNA methylthiolation	IBA
maintenance of translational fidelity	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

macromolecule modification [inference]

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	TAS
rough endoplasmic reticulum	IEA
membrane	HDA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

rough endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

rough endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 32814053
N6-threonylcarbomyladenosine methylthiotransferase activity	IBA
metal ion binding	IEA
4 iron, 4 sulfur cluster binding	IEA
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

alkylthioltransferase activity [inference]

methylthiotransferase activity [inference]

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

methylthiotransferase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
4 iron, 4 sulfur cluster binding
N6-threonylcarbomyladenosine methylthiotransferase activity
catalytic activity
iron-sulfur cluster binding
metal ion binding
methylthiotransferase activity
tRNA methylthiolation
transferase activity

Displaying **all 6** entries
InterPro
Elp3/MiaA/NifB-like, radical SAM core domain
Methylthiotransferase, N-terminal domain superfamily
Methylthiotransferase, N-terminal
Methylthiotransferase, conserved site
Radical SAM, alpha/beta horseshoe
Radical SAM

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:11714	gestational diabetes	Alliance of Genome Resources
DOID:8947	diabetic retinopathy	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	54901	Xenbase:XB-GENE-5895778
Mus musculus	68916	Xenbase:XB-GENE-5895778	MOUSE10846
Rattus norvegicus	361243		RATNO12073
Canis lupus familiaris	488240		CANLF13767
Bos taurus	530159		BOVIN19140
Macaca mulatta	706409		MACMU35751
Pan troglodytes	747778		PANTR37328
Equus caballus	100052309		HORSE18727
Ornithorhynchus anatinus	100083879		ORNAN30034
Taeniopygia guttata	100219317		TAEGU16871

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025