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CDK5 regulatory subunit associated protein 1 like 1

Summary

Gene Symbol

CDKAL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

54901

PubChem

54901

Alliance of Genome Resources

HGNC:21050

Annotation

Keyword

4Fe-4S
Alternative splicing
Diabetes mellitus
Endoplasmic reticulum
Phosphoprotein
Reference proteome
S-adenosyl-L-methionine
Transferase
Transmembrane helix
tRNA processing

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5VV42	CDK5 regulatory subunit-associated protein 1-like 1 tRNA-t(6)A37 methylthiotransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
tRNA methylthiolation	IBA
biological_process	ND
maintenance of translational fidelity	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

macromolecule modification [inference]

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	HDA	19946888
endoplasmic reticulum membrane	TAS
endoplasmic reticulum	IBA
rough endoplasmic reticulum	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

rough endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

rough endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 32814053
metal ion binding	IEA
4 iron, 4 sulfur cluster binding	IEA
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase	IEA
N6-threonylcarbomyladenosine methylthiotransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

alkylthioltransferase activity [inference]

methylthiotransferase activity [inference]

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uncharacterized protein

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
4 iron, 4 sulfur cluster binding
N6-threonylcarbomyladenosine methylthiotransferase activity
catalytic activity
iron-sulfur cluster binding
metal ion binding
methylthiotransferase activity
tRNA methylthiolation
transferase activity

Displaying **all 6** entries
InterPro
Elp3/MiaA/NifB-like, radical SAM core domain
Methylthiotransferase, N-terminal domain superfamily
Methylthiotransferase, N-terminal
Methylthiotransferase, conserved site
Radical SAM, alpha/beta horseshoe
Radical SAM

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:11714	gestational diabetes	Alliance of Genome Resources
DOID:8947	diabetic retinopathy	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	36954		FB:FBgn0034214
Mus musculus	68916		MGI:1921765	MOUSE10846
Caenorhabditis elegans	190786		WB:WBGene00022363
Rattus norvegicus	361243		RGD:1310246	RATNO12073
Danio rerio	393600		ZFIN:ZDB-GENE-040426-1443
Xenopus tropicalis	394802		Xenbase:XB-GENE-5895778
Xenopus laevis	432014		Xenbase:XB-GENE-5895849
Canis lupus familiaris	488240			CANLF13767
Bos taurus	530159			BOVIN19140
Macaca mulatta	706409			MACMU35751

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024