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ectonucleotide pyrophosphatase/phosphodiesterase 4

Summary

Gene Symbol

enpp4

Organism

Xenopus tropicalis (tropical clawed frog)

External Links

NCBI Gene

550082

PubChem

550082

Alliance of Genome Resources

Xenbase:XB-GENE-1013025

Annotation

Keyword

Blood coagulation
Cell membrane
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Reference proteome
Signal
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q0VA77	AP3A hydrolase Ectonucleotide pyrophosphatase/phosphodiesterase family member 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
blood coagulation	IEA

GO Hierarchy

biological process

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
hydrolase activity	IEA
bis(5'-adenosyl)-triphosphatase activity	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

bis(5'-adenosyl)-triphosphatase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
nucleoside triphosphate diphosphatase activity

Displaying **all 2** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

Rhea

H₂O + P¹,P³-bis(5'-adenosyl) triphosphate

H⁺ + AMP + ADP

Enzyme

3.6.1.29

PMID

Ortholog

Displaying entries **1 - 10** of **194** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	22875	9606_0:0018d9	HGNC:3359
Caenorhabditis elegans	177430		WB:WBGene00015283
Mus musculus	224794		MGI:2682634
Rattus norvegicus	301261		RGD:1308689
Gallus gallus	422055	9031_0:0012d6
Xenopus laevis	447221	8355_0:00491f	Xenbase:XB-GENE-1013030
Canis lupus familiaris	481823	9615_0:001e9b
Bos taurus	538583	9913_0:004211
Danio rerio	550586		ZFIN:ZDB-GENE-050417-444
Macaca mulatta	703680	9544_0:001358

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024