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oxidation resistance 1

Summary

Gene Symbol

OXR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

55074

PubChem

55074

Alliance of Genome Resources

HGNC:15822

JoGo

OXR1

TogoVar

OXR1

Annotation

Keyword

Alternative splicing
Disease variant
Epilepsy
Intellectual disability
Mitochondrion
Phosphoprotein
Proteomics identification
Reference proteome
Stress response

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N573

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
response to oxidative stress	NAS	11114193
response to oxidative stress	IBA
adult walking behavior	IEA
negative regulation of neuron apoptotic process	IEA
neuron apoptotic process	IEA

GO Hierarchy

biological process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to hydroperoxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to hydroperoxide

cellular response to oxygen-containing compound [inference]

cellular response to hydroperoxide

multicellular organismal process [inference]

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to hydroperoxide [inference]

cellular response to hydroperoxide

cellular response to oxidative stress [inference]

cellular response to hydroperoxide

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to hydroperoxide

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to hydroperoxide

cellular response to oxygen-containing compound [inference]

cellular response to hydroperoxide

response to oxygen-containing compound [inference]

response to hydroperoxide [inference]

cellular response to hydroperoxide

cellular response to oxygen-containing compound [inference]

cellular response to hydroperoxide

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to hydroperoxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to hydroperoxide

cellular response to oxygen-containing compound [inference]

cellular response to hydroperoxide

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

regulation of peptidyl-cysteine S-nitrosylation [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

regulation of peptidyl-cysteine S-nitrosylation [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

regulation of peptidyl-cysteine S-nitrosylation [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of peptidyl-cysteine S-nitrosylation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cellular response to oxidative stress

negative regulation of response to stimulus [inference]

negative regulation of response to oxidative stress [inference]

negative regulation of cellular response to oxidative stress

regulation of response to stimulus [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to oxidative stress [inference]

negative regulation of cellular response to oxidative stress

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress [inference]

negative regulation of cellular response to oxidative stress

regulation of response to oxidative stress [inference]

regulation of cellular response to oxidative stress [inference]

negative regulation of cellular response to oxidative stress

negative regulation of response to oxidative stress [inference]

negative regulation of cellular response to oxidative stress

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cellular response to oxidative stress

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress [inference]

negative regulation of cellular response to oxidative stress

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus	IBA
nucleolus	IEA
mitochondrion	IDA	15060142
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956
oxidoreductase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

oxidation resistance protein 1

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
response to oxidative stress

Displaying **all 3** entries
InterPro
LysM domain superfamily
LysM domain
TLDc domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070339	cerebellar hyplasia/atrophy, epilepsy, and global developmental delay	Alliance of Genome Resources

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Last updated: April 6, 2026

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Acknowledgements