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protein phosphatase 1 regulatory subunit 8

Summary

Gene Symbol

PPP1R8

Organism

Homo sapiens (human)

External Links

NCBI Gene

5511

PubChem

5511

Alliance of Genome Resources

HGNC:9296

JoGo

PPP1R8

TogoVar

PPP1R8

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
DNA-binding
Endonuclease
Magnesium
Nucleus
Phosphoprotein
Protein phosphatase inhibitor
Proteomics identification
RNA-binding
Reference proteome
Repeat
Repressor
Spliceosome
Transcription regulation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6ICT4
Q12972	Protein phosphatase 1 regulatory inhibitor subunit 8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mRNA processing	IEA
RNA catabolic process	TAS	9153239
cell population proliferation	IEA
RNA splicing	IEA
negative regulation of protein dephosphorylation

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA catabolic process

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA catabolic process

mRNA metabolic process [inference]

mRNA processing

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA catabolic process

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA catabolic process

mRNA metabolic process [inference]

mRNA processing

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA catabolic process

mRNA metabolic process [inference]

mRNA processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA catabolic process

mRNA metabolic process [inference]

mRNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA catabolic process

mRNA metabolic process [inference]

mRNA processing

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular process [inference]

cell population proliferation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA catabolic process

mRNA metabolic process [inference]

mRNA processing

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA catabolic process

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA catabolic process

mRNA metabolic process [inference]

mRNA processing

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of protein dephosphorylation

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
nucleus	TAS	7499293
nucleoplasm	TAS
nucleoplasm	IDA
spliceosomal complex	IEA
cytoplasm	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

spliceosomal complex

ribonucleoprotein complex [inference]

spliceosomal complex

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
DNA binding	IEA
RNA binding	TAS	9153239
mRNA binding	IBA
endonuclease activity	IEA
protein serine/threonine phosphatase inhibitor activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity

RNA nuclease activity [inference]

ribonuclease E activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

ribonuclease E activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

RNA binding

mRNA binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

phosphatase inhibitor activity [inference]

protein phosphatase inhibitor activity [inference]

protein serine/threonine phosphatase inhibitor activity

phosphatase regulator activity [inference]

phosphatase inhibitor activity [inference]

protein phosphatase inhibitor activity [inference]

protein serine/threonine phosphatase inhibitor activity

protein phosphatase regulator activity [inference]

protein phosphatase inhibitor activity [inference]

protein serine/threonine phosphatase inhibitor activity

molecular function inhibitor activity

enzyme inhibitor activity [inference]

phosphatase inhibitor activity [inference]

protein phosphatase inhibitor activity [inference]

protein serine/threonine phosphatase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5'-nucleotidase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
5'-nucleotidase activity
hydrolase activity
magnesium ion binding
metal ion binding
nucleotide binding
nucleotide metabolic process

Displaying **all 3** entries
InterPro
HAD superfamily
HAD-like superfamily
Pyrimidine 5'-nucleotidase, eukaryotic

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements