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ATPase family AAA domain containing 3A

Summary

Gene Symbol

ATAD3A

Organism

Homo sapiens (human)

External Links

NCBI Gene

55210

PubChem

55210

Alliance of Genome Resources

HGNC:25567

JoGo

ATAD3A

TogoVar

ATAD3A

Annotation

Keyword

ATP-binding
Acetylation
Alternative splicing
Coiled coil
Direct protein sequencing
Disease variant
Hydrolase
Mitochondrion inner membrane
Mitochondrion nucleoid
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NVI7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
regulation of cell growth	IMP	20332122
cellular response to DNA damage stimulus	IDA	37832546
DNA damage response	IDA	37832546
mitochondrion organization	IMP	20154147
mitochondrion organization	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response [inference]

antiviral innate immune response

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

integrated stress response signaling [inference]

HRI-mediated signaling

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

antiviral innate immune response

defense response to other organism [inference]

innate immune response [inference]

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

antiviral innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

antiviral innate immune response

cellular response to stress [inference]

cellular response to DNA damage stimulus

integrated stress response signaling [inference]

HRI-mediated signaling

immune response [inference]

innate immune response [inference]

antiviral innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

antiviral innate immune response

defense response to other organism [inference]

innate immune response [inference]

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

antiviral innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

antiviral innate immune response

defense response to other organism [inference]

innate immune response [inference]

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

antiviral innate immune response

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

integrated stress response signaling [inference]

HRI-mediated signaling

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of PERK-mediated unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of growth [inference]

regulation of cell growth

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of PERK-mediated unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of PERK-mediated unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of PERK-mediated unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of cellular component organization [inference]

regulation of cell growth

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

regulation of PERK-mediated unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of PERK-mediated unfolded protein response

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrion	IDA	20332122
mitochondrion	IBA
mitochondrion	HTP	34800366
mitochondrial inner membrane	IDA	20154147 20349121
mitochondrial nucleoid	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoid [inference]

mitochondrial nucleoid

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

mitochondrial nucleoid

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular non-membrane-bounded organelle [inference]

mitochondrial nucleoid

organelle membrane contact site [inference]

mitochondria-associated endoplasmic reticulum membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	22664726 30914652 31522117
ATP binding	IMP	20154147
ATP hydrolysis activity	IMP	20154147 39116259
protein serine/threonine kinase inhibitor activity	IDA	39116259
identical protein binding	IPI	30914652

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein serine/threonine kinase inhibitor activity

kinase regulator activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein serine/threonine kinase inhibitor activity

protein kinase regulator activity [inference]

protein kinase inhibitor activity [inference]

protein serine/threonine kinase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein serine/threonine kinase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Atpase family aaa domain-containing protein

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis

Displaying **all 4** entries
Gene Ontology
ATP binding
mitochondrion organization
nucleotide binding
zinc ion binding

Displaying **all 5** entries
InterPro
AAA+ ATPase domain
ATPase family AAA domain-containing protein 3, N-terminal
ATPase family AAA domain-containing protein 3
ATPase, AAA-type, core
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0081395	Harel-Yoon syndrome	Alliance of Genome Resources
DOID:0081396	neonatal lethal pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements