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nei like DNA glycosylase 3

Summary

Gene Symbol

NEIL3

Aliases

FLJ10858
FPG2
ZGRF3
hFPG2
hNEI3
zinc finger, GRF-type containing 3

Organism

Homo sapiens (human)

External Links

NCBI Gene

55247

HGNC

24573

PubChem

55247

Alliance of Genome Resources

HGNC:24573

Annotation

Keyword

3D-structure
Chromosome
DNA repair
DNA-binding
Glycosidase
Lyase
Multifunctional enzyme
Nucleus
Phosphoprotein
Reference proteome
Repeat
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TAT5	DNA glycosylase FPG2 DNA glycosylase/AP lyase Neil3 Endonuclease VIII-like 3 Nei-like protein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
base-excision repair, AP site formation	TAS
base-excision repair	IBA IDA ISS	23755964
interstrand cross-link repair	ISS
depurination	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

DNA modification [inference]

depurination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

depurination

DNA modification [inference]

depurination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IBA IDA	12433996
chromosome	IEA
nucleoplasm	IDA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	PMID
double-stranded DNA binding	ISS
DNA N-glycosylase activity	IBA IDA ISS TAS	23755964
zinc ion binding	IEA
single-stranded DNA binding	IDA	19170771
DNA-(apurinic or apyrimidinic site) endonuclease activity	IBA IDA	19170771

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA-(apurinic or apyrimidinic site) endonuclease activity

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA N-glycosylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

MCM complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

DNA secondary structure binding [inference]

bubble DNA binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying entries **1 - 10** of 16 in total

1

2

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DO ID	Disease Name	Source
DOID:0080525	differentiated thyroid gland carcinoma	DisGeNET
DOID:10952	nephritis	DisGeNET
DOID:11847	coronary thrombosis	DisGeNET
DOID:13636	Fanconi anemia	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:2513	basal cell carcinoma	DisGeNET
DOID:2921	glomerulonephritis	DisGeNET
DOID:3068	glioblastoma	DisGeNET DisGeNET
DOID:3074	giant cell glioblastoma	DisGeNET
DOID:3571	liver cancer	DisGeNET

Ortholog

Displaying entries **1 - 10** of 74 in total

1

2

3

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5

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	492463	ZFIN:ZDB-GENE-041114-18	DANRE07885
Ictalurus punctatus	108268715		ICTPU34811
Electrophorus electricus	113579935		ELEEL22354
Salmo salar	106604520		SALSA123320
Salmo trutta	115170776		SALTR45434
Gadus morhua	115552539		GADMO01034
Oryzias latipes	101159899		ORYLA20431
Oreochromis niloticus	100707610		ORENI48367
Sparus aurata	115569150		SPAAU63745
Xenopus laevis	100380996	Xenbase:XB-GENE-1001617

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024