GlyCosmos Portal

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Disease variant
Endoplasmic reticulum
Golgi apparatus
Hydrolase
Leukodystrophy
Lipid metabolism
Metal-binding
Proteomics identification
Reference proteome
Sphingolipid metabolism
Transmembrane helix
Zinc

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7Z2V2
Q9NUN7	Alkaline dihydroceramidase SB89 Alkaline phytoceramidase
B7Z2Q2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
myelination	IMP	26792856
ceramide biosynthetic process
sphingosine biosynthetic process	IDA IMP	20068046 20207939 26792856
ceramide catabolic process	IDA IMP	20207939 26792856 30575723
inflammatory response	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

amide metabolic process [inference]

ceramide metabolic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

cellular process [inference]

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA IDA TAS	11356846
membrane	IDA	30575723
Golgi membrane	IDA	11356846

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
phytoceramidase activity	IBA IDA IMP	11356846 20068046 26792856
N-acylsphingosine amidohydrolase activity	IDA IMP	20068046 20207939 30575723
zinc ion binding	IDA	30575723
ceramidase activity	IEA
dihydroceramidase activity	IDA IMP	20068046 20207939

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

N-acylsphingosine amidohydrolase activity

ceramidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000078124

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K04711

Name

dihydroceramidase [EC:3.5.1.-]

References

11356846

Rhea

RHEA:20856

H₂O + an N-acylsphing-4-enine

a fatty acid + sphing-4-enine

Enzyme

3.5.1.23

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 19 in total

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DO ID	Disease Name	Source
DOID:0050753	cerebellar ataxia	DisGeNET
DOID:0080547	metabolic dysfunction-associated steatohepatitis	Alliance of Genome Resources
DOID:10579	leukodystrophy	DisGeNET Alliance of Genome Resources
DOID:1059	intellectual disability	DisGeNET
DOID:11577	Cauda equina syndrome	DisGeNET
DOID:12143	neurogenic bladder	DisGeNET
DOID:1443	cerebral degeneration	DisGeNET
DOID:1909	melanoma	DisGeNET
DOID:2786	cerebellar disease	DisGeNET
DOID:3571	liver cancer	DisGeNET

The Human Phenotype Ontology

Displaying entries **21 - 24** of 24 in total

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HPO ID	HPO Term
HP:0007281	Developmental stagnation
HP:0008936	Axial hypotonia
HP:0009830	Peripheral neuropathy
HP:0010864	Intellectual disability, severe

Displaying 1 entry
Disease ID	Disease Name
OMIM:617762	alkaline ceramidase 3 deficiency

PubChem Disease

MedGen Diseases

Alkaline ceramidase 3 deficiency

OMIM Phenotypes

LEUKODYSTROPHY, PROGRESSIVE, EARLY CHILDHOOD-ONSET; PLDECO

KEGG Diseases

Early childhood-onset progressive leukodystrophy

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001699
Gene Name: alkaline ceramidase 3

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	555411	ZFIN:ZDB-GENE-091204-155	DANRE00351
Astyanax mexicanus	103042148		ASTMX02985
Ictalurus punctatus	108276919		ICTPU09481
Electrophorus electricus	113580729		ELEEL26978
Salmo salar	106567925		SALSA28726
Salmo salar	106603557		SALSA121232
Salmo trutta	115148915		SALTR20485
Salmo trutta	115154373		SALTR103673
Gadus morhua	115547828		GADMO54642
Oreochromis niloticus	100710861		ORENI03093

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements