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solute carrier family 35 member C1

Summary

Gene Symbol

SLC35C1

Aliases

FLJ11320
FUCT1
GDP-fucose transporter 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

55343

GGDB ID

gg173

HGNC

20197

mRNA

NM_018389

map

11p11.2

Protein

NP_060859

OMIM

605881

KEGG Gene ID

hsa:55343

PubChem

55343

Alliance of Genome Resources

HGNC:20197

Annotation

Keyword

Alternative splicing
Congenital disorder of glycosylation
Disease variant
Golgi apparatus
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q96A29	Solute carrier family 35 member C1
B3KQH0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
GDP-fucose import into Golgi lumen	IBA IDA	11326280
lipid glycosylation	IEA
negative regulation of Notch signaling pathway	IEA
protein O-linked fucosylation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

glycosylation [inference]

lipid glycosylation

fucosylation [inference]

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

transmembrane transport [inference]

nucleotide-sugar transmembrane transport [inference]

purine nucleotide-sugar transmembrane transport [inference]

GDP-fucose transmembrane transport [inference]

GDP-fucose import into Golgi lumen

cytosol to Golgi apparatus transport [inference]

GDP-fucose import into Golgi lumen

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport [inference]

nucleotide-sugar transmembrane transport [inference]

purine nucleotide-sugar transmembrane transport [inference]

GDP-fucose transmembrane transport [inference]

GDP-fucose import into Golgi lumen

cytosol to Golgi apparatus transport [inference]

GDP-fucose import into Golgi lumen

organic substance transport [inference]

nucleobase-containing compound transport [inference]

nucleotide-sugar transmembrane transport [inference]

purine nucleotide-sugar transmembrane transport [inference]

GDP-fucose transmembrane transport [inference]

GDP-fucose import into Golgi lumen

carbohydrate derivative transport [inference]

nucleotide-sugar transmembrane transport [inference]

purine nucleotide-sugar transmembrane transport [inference]

GDP-fucose transmembrane transport [inference]

GDP-fucose import into Golgi lumen

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide-sugar transmembrane transport [inference]

purine nucleotide-sugar transmembrane transport [inference]

GDP-fucose transmembrane transport [inference]

GDP-fucose import into Golgi lumen

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IBA IDA
Golgi membrane	IDA TAS	11326279

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
GDP-fucose transmembrane transporter activity	IBA IDA TAS	27738779
antiporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

nucleobase-containing compound transmembrane transporter activity [inference]

nucleotide-sugar transmembrane transporter activity [inference]

purine nucleotide-sugar transmembrane transporter activity [inference]

GDP-fucose transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

carbohydrate derivative transmembrane transporter activity [inference]

nucleotide-sugar transmembrane transporter activity [inference]

purine nucleotide-sugar transmembrane transporter activity [inference]

GDP-fucose transmembrane transporter activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000181830

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg173

Gene Symbol

SLC35C1

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Rattus norvegicus	XP_230292	XM_230292
Drosophila melanogaster	NP_649782	NM_141525
Caenorhabditis elegans	NP_505467	NM_073066
Mus musculus	NP_997597	NM_211358

KEGG BRITE Database

Orthology

K15279

Name

solute carrier family 35 (GDP-fucose transporter), member C1

References

12759756

Disease

Disease Ontology

Displaying entries **11 - 13** of 13 in total

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DO ID	Disease Name	Source
DOID:6612	leukocyte adhesion deficiency	DisGeNET
DOID:684	hepatocellular carcinoma	DisGeNET
DOID:9521	Laron syndrome	DisGeNET

The Human Phenotype Ontology

Displaying entries **41 - 50** of 75 in total

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HPO ID	HPO Term
HP:0001935	Microcytic anemia
HP:0001939	Abnormality of metabolism/homeostasis
HP:0001954	Recurrent fever
HP:0001974	Leukocytosis
HP:0002002	Deep philtrum
HP:0002028	Chronic diarrhea
HP:0002059	Cerebral atrophy
HP:0002090	Pneumonia
HP:0002120	Cerebral cortical atrophy
HP:0002240	Hepatomegaly

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:266265	leukocyte adhesion deficiency type II
ORPHA:99843	leukocyte adhesion deficiency type II

PubChem Disease

MedGen Diseases

Leukocyte adhesion deficiency type II

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIc; CDG2C

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179342	WB:WBGene00008237
Caenorhabditis elegans	188685	WB:WBGene00011882
Drosophila melanogaster	40981	FB:FBgn0265351
Ciona intestinalis	100186387		CIOIN05417
Callorhinchus milii	103175030		CALMI06873
Danio rerio	494047	ZFIN:ZDB-GENE-041212-11	DANRE41807
Astyanax mexicanus	103034845		ASTMX18138
Ictalurus punctatus	108271163		ICTPU01937
Electrophorus electricus	113586064		ELEEL36871
Salmo salar	106587780		SALSA93433

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements