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sphingomyelin phosphodiesterase 3

Summary

Gene Symbol

SMPD3

Aliases

NSMASE2
neutral sphingomyelinase II

Organism

Homo sapiens (human)

External Links

NCBI Gene

55512

HGNC

14240

KEGG Gene ID

hsa:55512

PubChem

55512

Alliance of Genome Resources

HGNC:14240

Annotation

Keyword

3D-structure
Alternative splicing
Cell cycle
Cell membrane
Developmental protein
Golgi apparatus
Hydrolase
Magnesium
Metal-binding
Palmitate
Phosphoprotein
Reference proteome
Sphingolipid metabolism
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8K0T6
Q9NY59	Neutral sphingomyelinase 2 Neutral sphingomyelinase II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
endochondral ossification	IEA
bone growth	IEA
lung alveolus development	IEA
G1 to G0 transition	IEA
cellular response to hydrogen peroxide	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

amide metabolic process [inference]

ceramide metabolic process

sphingomyelin metabolic process

sphingomyelin catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingomyelin metabolic process

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

collagen metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingomyelin metabolic process

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingomyelin metabolic process

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingomyelin metabolic process

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingomyelin metabolic process

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

sphingolipid mediated signaling pathway

cell cycle process [inference]

G1 to G0 transition

mitotic cell cycle process [inference]

mitotic nuclear division

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingomyelin metabolic process

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to magnesium ion

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to organonitrogen compound [inference]

cellular response to peptide

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to peptide

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus [inference]

cellular response to oxidised low-density lipoprotein particle stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle fission [inference]

nuclear division [inference]

mitotic nuclear division

cellular component assembly [inference]

extracellular matrix assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

multicellular organismal process [inference]

ossification [inference]

replacement ossification [inference]

endochondral ossification

multicellular organism growth

organ growth [inference]

bone growth

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth [inference]

dentinogenesis

anatomical structure formation involved in morphogenesis [inference]

dentinogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

lung alveolus development

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis

growth [inference]

developmental growth [inference]

multicellular organism growth

organ growth [inference]

bone growth

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to endogenous stimulus [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus [inference]

cellular response to oxidised low-density lipoprotein particle stimulus

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus [inference]

cellular response to oxidised low-density lipoprotein particle stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide

response to peptide [inference]

cellular response to peptide

response to cytokine [inference]

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to organonitrogen compound [inference]

cellular response to peptide

response to inorganic substance [inference]

response to metal ion [inference]

response to magnesium ion [inference]

cellular response to magnesium ion

cellular response to metal ion [inference]

cellular response to magnesium ion

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to magnesium ion

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to magnesium ion

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to organonitrogen compound [inference]

cellular response to peptide

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to peptide

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus [inference]

cellular response to oxidised low-density lipoprotein particle stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide

response to peptide [inference]

cellular response to peptide

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

response to peptide [inference]

cellular response to peptide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to peptide

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to magnesium ion

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to organonitrogen compound [inference]

cellular response to peptide

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to peptide

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus [inference]

cellular response to oxidised low-density lipoprotein particle stimulus

response to redox state [inference]

cellular response to redox state

localization [inference]

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion

secretion [inference]

peptide secretion [inference]

peptide hormone secretion

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

organic substance transport [inference]

carbohydrate transport [inference]

polysaccharide transport

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion

nitrogen compound transport [inference]

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of leukocyte migration

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide metabolic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of polysaccharide metabolic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation

positive regulation of cellular component biogenesis [inference]

positive regulation of exosomal secretion

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of cartilage development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

sphingolipid mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of exosomal secretion

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation

positive regulation of cellular component biogenesis [inference]

positive regulation of exosomal secretion

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

regulation of nuclear division [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division

regulation of cell cycle process [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of cartilage development

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
cytoplasm	IBA
Golgi cis cisterna	IEA
plasma membrane	ISS TAS
Golgi membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi cisterna [inference]

Golgi cis cisterna

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
phosphatidylserine binding	ISS
sphingomyelin phosphodiesterase activity	IBA IDA ISS	14741383
phosphatidic acid binding	ISS
neutral sphingomyelin phosphodiesterase activity	IEA
phosphoric diester hydrolase activity	IDA	14741383

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

sphingomyelin phosphodiesterase activity

neutral sphingomyelin phosphodiesterase activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity

sphingomyelin phosphodiesterase activity

neutral sphingomyelin phosphodiesterase activity

binding [inference]

protein binding

identical protein binding

lipid binding [inference]

phospholipid binding [inference]

ion binding [inference]

anion binding [inference]

phosphatidic acid binding

cation binding [inference]

metal ion binding

modified amino acid binding [inference]

phosphatidylserine binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000103056

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K12352

Name

sphingomyelin phosphodiesterase 3 [EC:3.1.4.12]

References

Rhea

H₂O + a sphingomyelin

H⁺ + phosphocholine + an N-acylsphing-4-enine

Enzyme

3.1.4.12

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **112** in total

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DO ID	Disease Name	Source
DOID:0050459	hyperphosphatemia	DisGeNET
DOID:0050635	alternating hemiplegia of childhood	DisGeNET
DOID:0050908	myelodysplastic syndrome	DisGeNET DisGeNET
DOID:0060478	Zika fever	DisGeNET
DOID:0060870	isolated growth hormone deficiency	DisGeNET DisGeNET
DOID:0060872	isolated growth hormone deficiency type II	DisGeNET DisGeNET
DOID:0060873	isolated growth hormone deficiency type IA	DisGeNET DisGeNET
DOID:0060874	isolated growth hormone deficiency type IB	DisGeNET DisGeNET
DOID:0060875	isolated growth hormone deficiency type III	DisGeNET DisGeNET
DOID:0060891	Parkinson's disease 19A	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001258
Gene Name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callorhinchus milii	103185923		CALMI33491
Latimeria chalumnae	102351710		LATCH04647
Danio rerio	568381	ZFIN:ZDB-GENE-081104-280	DANRE26884
Ictalurus punctatus	108269327		ICTPU34502
Salmo salar	106560916		SALSA51719
Salmo salar	106573651		SALSA81771
Salmo trutta	115151865		SALTR114365
Gadus morhua	115551276		GADMO61061
Oryzias latipes	101170408		ORYLA20310
Sparus aurata	115586630		SPAAU44587

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Last updated: August 19, 2024