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MIRAGE
protein kinase AMP-activated catalytic subunit alpha 2
Summary
- Gene Symbol
-
- PRKAA2
- Aliases
-
- AMPK
- AMPKa2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Autophagy
- Biological rhythms
- Cholesterol biosynthesis
- Chromatin regulator
- Cytoplasm
- Fatty acid biosynthesis
- Magnesium
- Metal-binding
- Nucleus
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Transcription regulation
- Ubl conjugation
- Wnt signaling pathway
- Proteins
| UniProt | Protein Name |
|---|---|
| P54646 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| energy homeostasis | ||
| cholesterol biosynthetic process | ||
| fatty acid homeostasis | ||
| protein phosphorylation | ||
| lipid droplet disassembly |
GO Hierarchy
- rhythmic process
- regulation of circadian rhythm
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of phosphorus metabolic process [inference]
positive regulation of cellular process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| ATP binding | ||
| [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity | ||
| protein serine/threonine/tyrosine kinase activity | ||
| metal ion binding | ||
| AMP-activated protein kinase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- kinase
- Functional Category
-
- E: Amino acid transport and metabolism
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| InterPro |
|---|
| Protein kinase domain |
| Protein kinase, ATP binding site |
| Protein kinase-like domain superfamily |
| Serine/threonine-protein kinase, active site |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:14330 | Parkinson's disease | |
| DOID:9352 | type 2 diabetes mellitus | |
| DOID:9970 | obesity |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 43904 | FB:FBgn0023169 | |||
| 78975 | RGD:620893 | RATNO33692 | ||
| 108079 | MGI:1336173 | MOUSE39516 | ||
| 397504 | PIGXX30297 | |||
| 538954 | BOVIN26865 | |||
| 572074 | ZFIN:ZDB-GENE-081120-5 | DANRE20331 | ||
| 717703 | MACMU24169 | |||
| 741802 | 9598_0:00090f | PANTR21209 | ||
| 780945 | MELGA02467 | |||
| 852088 | SGD:S000002885 |
