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NOP2/Sun RNA methyltransferase 5

Summary

Gene Symbol

NSUN5

Organism

Homo sapiens (human)

External Links

NCBI Gene

55695

PubChem

55695

Alliance of Genome Resources

HGNC:16385

JoGo

NSUN5

TogoVar

NSUN5

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Direct protein sequencing
Methyltransferase
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
S-adenosyl-L-methionine
Williams-Beuren syndrome
rRNA processing

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96P11	NOL1-related protein NOL1/NOP2/Sun domain family member 5 Williams-Beuren syndrome chromosomal region 20A protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
oligodendrocyte development	ISS
cerebral cortex development	ISS
corpus callosum development	ISS
regulation of myelination	ISS
positive regulation of translation	IMP	31428936 31722427

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

methylation [inference]

macromolecule methylation [inference]

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation

macromolecule methylation [inference]

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

ncRNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

oligodendrocyte development

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

glial cell development [inference]

oligodendrocyte development

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

oligodendrocyte development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

regulation of myelination

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleoplasm	IDA
nucleolus	IDA	31722427
nucleolus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
rRNA (cytosine-C5-)-methyltransferase activity	IDA	31428936 31722427

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

C-methyltransferase activity [inference]

rRNA (cytosine-C5-)-methyltransferase activity

RNA methyltransferase activity [inference]

rRNA methyltransferase activity [inference]

rRNA (cytosine) methyltransferase activity [inference]

rRNA (cytosine-C5-)-methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity [inference]

rRNA methyltransferase activity [inference]

rRNA (cytosine) methyltransferase activity [inference]

rRNA (cytosine-C5-)-methyltransferase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA methyltransferase activity [inference]

rRNA methyltransferase activity [inference]

rRNA (cytosine) methyltransferase activity [inference]

rRNA (cytosine-C5-)-methyltransferase activity

catalytic activity, acting on a rRNA [inference]

rRNA methyltransferase activity [inference]

rRNA (cytosine) methyltransferase activity [inference]

rRNA (cytosine-C5-)-methyltransferase activity

binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

methyltransferase

Functional Category

K: Transcription
L: Replication, recombination and repair
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 6** entries
Gene Ontology
RNA methylation
RNA methyltransferase activity
S-adenosylmethionine-dependent methyltransferase activity
methylation
rRNA base methylation
transferase activity

Displaying **all 6** entries
InterPro
NOL1/NOP2/NSUN 5/7, ferredoxin-like domain
NSUN5/RCM1, N-terminal domain
RNA (C5-cytosine) methyltransferase
S-adenosyl-L-methionine-dependent methyltransferase superfamily
SAM-dependent methyltransferase RsmB-F/NOP2-type domain
SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements