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Guidelines

MIRAGE

UDP-glucose glycoprotein glucosyltransferase 2

Summary

Gene Symbol

UGGT2

Aliases

FLJ10873
FLJ11485
HUGT2
MGC117360
MGC150689
MGC87276
UDP-glucose:glycoprotein glucosyltransferase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

55757

GGDB ID

gg153

HGNC

15664

mRNA

NM_020121

map

13q32.1

Protein

NP_064506

OMIM

605898

KEGG Gene ID

hsa:55757

PubChem

55757

Alliance of Genome Resources

HGNC:15664

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Phosphoprotein
Proteomics identification
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q05D90
Q9NYU1	UDP--Glc:glycoprotein glucosyltransferase 2 UDP-glucose ceramide glucosyltransferase-like 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation via asparagine	IBA
ERAD pathway
UDP-glucosylation	IEA
endoplasmic reticulum mannose trimming	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

phosphorus metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

protein deglycosylation [inference]

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

endoplasmic reticulum mannose trimming

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

phosphorus metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-glucose metabolic process [inference]

UDP-glucosylation

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA
endoplasmic reticulum lumen	ISS
endoplasmic reticulum lumen	TAS
endoplasmic reticulum-Golgi intermediate compartment	IEA
protein-containing complex	IDA	23349634

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum quality control compartment

Displaying **all 5** entries
GO Term	Evidence Code	PMID
UDP-glucose:glycoprotein glucosyltransferase activity	ISS
UDP-glucose:glycoprotein glucosyltransferase activity	TAS
UDP-glucose:glycoprotein glucosyltransferase activity	IBA
protein binding	IPI	23349634 25416956 33961781 36217029
unfolded protein binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-glucosyltransferase activity [inference]

UDP-glucose:glycoprotein glucosyltransferase activity

hexosyltransferase activity [inference]

glucosyltransferase activity [inference]

UDP-glucosyltransferase activity [inference]

UDP-glucose:glycoprotein glucosyltransferase activity

binding [inference]

protein binding

unfolded protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

udp-glucose glycoprotein glucosyltransferase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
UDP-glucose
UDP-glucosylation
protein N-linked glycosylation via asparagine
transferase activity
unfolded protein binding

Displaying **all 7** entries
InterPro
Glucosyltransferase 24, catalytic domain
Nucleotide-diphospho-sugar transferases
UDP-glucose
UDP-glucose
UGGT, thioredoxin-like domain 1
UGGT, thioredoxin-like domain 2
UGGT, thioredoxin-like domain 3

GlycoGene Database (GGDB)

GGDB ID

gg153

Gene Symbol

UGGT2

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Glc	G60230HH	MTX	G19958IL	MTX	24415556

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Glc	G60230HH	MTX	G19958IL	MTX	24415556

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Mus musculus	BAC34847	AK052077
Rattus norvegicus	XP_224524	XM_224524

KEGG BRITE Database

Orthology

K11718

Name

UDP-glucose:glycoprotein glucosyltransferase [EC:2.4.1.-]

References

10694380

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006809
Gene Name: UDP-glucose glycoprotein glucosyltransferase 2

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025