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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
protein kinase C alpha
Summary
- Gene Symbol
-
- PRKCA
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Angiogenesis
- Apoptosis
- Calcium
- Cell adhesion
- Cell membrane
- Cytoplasm
- Direct protein sequencing
- Metal-binding
- Mitochondrion
- Nucleus
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- Repeat
- Serine/threonine-protein kinase
- Zinc
- Zinc-finger
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of mRNA stability | ||
| positive regulation of angiotensin-activated signaling pathway | ||
| negative regulation of glial cell apoptotic process | ||
| positive regulation of macrophage differentiation | ||
| positive regulation of cell adhesion |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| mitochondrial membrane | ||
| alphav-beta3 integrin-PKCalpha complex | ||
| plasma membrane | ||
| nucleoplasm | ||
| mitochondrion |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| protein serine kinase activity | ||
| integrin binding | ||
| zinc ion binding | ||
| diacylglycerol binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- kinase
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| transferase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060074 | ductal carcinoma in situ | |
| DOID:10286 | prostate carcinoma | |
| DOID:10763 | hypertension | |
| DOID:11054 | urinary bladder cancer | |
| DOID:12930 | dilated cardiomyopathy | |
| DOID:1574 | alcohol use disorder | |
| DOID:2316 | brain ischemia | |
| DOID:2394 | ovarian cancer | |
| DOID:2871 | endometrial carcinoma | |
| DOID:3070 | high grade glioma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 18750 | MGI:97595 | MOUSE06398 | ||
| 24680 | RGD:3395 | RATNO02287 | ||
| 36897 | FB:FBgn0004784 | |||
| 48311 | FB:FBgn0003091 | |||
| 181166 | WB:WBGene00004033 | |||
| 282001 | BOVIN14130 | |||
| 447031 | Xenbase:XB-GENE-5942910 | |||
| 454832 | 9598_0:0046ae | PANTR15250 | ||
| 497384 | ZFIN:ZDB-GENE-050208-100 | DANRE39435 | ||
| 718412 | MACMU15709 |
