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cytidine monophosphate N-acetylneuraminic acid synthetase

Summary

Gene Symbol

CMAS

Aliases

CMP-Neu5Ac synthetase
N-acylneuraminate cytidylyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

55907

HGNC

18290

KEGG Gene ID

hsa:55907

PubChem

55907

Alliance of Genome Resources

HGNC:18290

Annotation

Keyword

Acetylation
Alternative splicing
Direct protein sequencing
Methylation
Nucleotidyltransferase
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NFW8	CMP-N-acetylneuraminic acid synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
N-acetylneuraminate metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

N-acetylneuraminate metabolic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

N-acetylneuraminate metabolic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	HDA	21630459
membrane	HDA	19946888
nucleoplasm

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying 1 entry
GO Term	Evidence Code	PMID
N-acylneuraminate cytidylyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

cytidylyltransferase activity [inference]

N-acylneuraminate cytidylyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000111726

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K21749

Name

N-acylneuraminate/3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase [EC:2.7.7.43 2.7.7.92]

References

Rhea

CTP + an N-acylneuraminate

diphosphate + a CMP-N-acyl-β-neuraminate

Enzyme

2.7.7.43

PMID

Disease

Disease Ontology

Displaying entries **31 - 40** of 51 in total

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DO ID	Disease Name	Source
DOID:4465	papillary renal cell carcinoma	DisGeNET DisGeNET
DOID:4467	clear cell renal cell carcinoma	DisGeNET DisGeNET
DOID:4471	chromophobe renal cell carcinoma	DisGeNET DisGeNET
DOID:4473	sarcomatoid renal cell carcinoma	DisGeNET DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:5082	liver cirrhosis	DisGeNET
DOID:5520	head and neck squamous cell carcinoma	DisGeNET
DOID:5672	large intestine cancer	DisGeNET
DOID:612	primary immunodeficiency disease	DisGeNET
DOID:6193	epithelioid sarcoma	DisGeNET

Ortholog

Displaying entries **71 - 80** of 89 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Kryptolebias marmoratus	108228449		KRYMA29134
Aotus nancymaae	105720544		AOTNA24394
Saimiri boliviensis boliviensis	101042258		SAIBB11138
Ictidomys tridecemlineatus	101968251		ICTTR16958
Jaculus jaculus	101603617		JACJA15880
Rhinolophus ferrumequinum	117029190		RHIFE08502
Taeniopygia guttata	100225966		TAEGU08137
Chlorocebus sabaeus	103218742		CHLSB02033
Rhinopithecus bieti	108541109		RHIBE08569
Rhinopithecus roxellana	104660755		RHIRO37646

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Last updated: August 19, 2024