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catechol-O-methyltransferase a

Summary

Gene Symbol

comta

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

561372

PubChem

561372

Alliance of Genome Resources

ZFIN:ZDB-GENE-050913-117

Annotation

Keyword

Alternative splicing
Catecholamine metabolism
Glycoprotein
Magnesium
Metal-binding
Methyltransferase
Neurotransmitter degradation
Reference proteome
S-adenosyl-L-methionine
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
F4ZGF2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
catecholamine catabolic process	IBA
dopamine metabolic process	IBA
developmental process	IBA
methylation	IEA
catecholamine metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

methylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

organonitrogen compound metabolic process [inference]

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

developmental process

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
metal ion binding	IEA
catechol O-methyltransferase activity	IBA IDA IEA	21371608
O-methyltransferase activity	IEA
transferase activity	IEA
magnesium ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity

O-methyltransferase activity

catechol O-methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity [inference]

catechol O-methyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

magnesium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

o-methyltransferase

Functional Category

H: Coenzyme transport and metabolism
J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis

Displaying **all 6** entries
Gene Ontology
O-methyltransferase activity
catecholamine catabolic process
catecholamine metabolic process
dopamine metabolic process
methylation
transferase activity

Displaying **all 2** entries
InterPro
Class I-like SAM-dependent O-methyltransferase
S-adenosyl-L-methionine-dependent methyltransferase superfamily

Disease

Disease Ontology

Displaying entries **1 - 10** of 40 in total

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DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:0060001	withdrawal disorder	Alliance of Genome Resources
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10933	obsessive-compulsive disorder	Alliance of Genome Resources
DOID:1094	attention deficit hyperactivity disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **283** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1312		HGNC:2228	HUMAN59230
Mus musculus	12846		MGI:88470	MOUSE19552
Rattus norvegicus	24267		RGD:2379	RATNO04095
Canis lupus familiaris	445450			CANLF10595
Pan troglodytes	458655			PANTR25982
Xenopus tropicalis	549111		Xenbase:XB-GENE-948947
Xenopus tropicalis	549911		Xenbase:XB-GENE-5865481
Macaca mulatta	712548			MACMU00872
Sus scrofa	100155530			PIGXX07450
Taeniopygia guttata	100223814			TAEGU05974

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024