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ADP-ribosylation factor-like 6

Summary

Gene Symbol

Arl6

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

56297

PubChem

56297

Alliance of Genome Resources

MGI:1927136

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Cilium biogenesis/degradation
Cytoplasm
Cytoskeleton
GTP-binding
Magnesium
Metal-binding
Myristate
Protein transport
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3TUM2
O88848

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 16 in total

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GO Term	Evidence Code	PMID
Ras protein signal transduction	ISS	10508919
fat cell differentiation	IEP	17379567
vesicle-mediated transport	IBA
intracellular protein transport	IBA
protein localization to cilium	IBA ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

vesicle-mediated transport

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium

protein localization to non-motile cilium

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

protein-containing complex assembly [inference]

protein polymerization

organelle assembly [inference]

cilium assembly

cell projection organization

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization

membrane organization [inference]

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

retina layer formation

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium

protein localization to non-motile cilium

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

intracellular transport [inference]

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

organic substance transport [inference]

protein transport

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

nitrogen compound transport [inference]

protein transport

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium

protein localization to non-motile cilium

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway

Displaying entries **11 - 12** of 12 in total

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GO Term	Evidence Code	PMID
membrane	IDA IMP	10508919 22139371
ciliary membrane

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

membrane coat

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

cell projection

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

microtubule cytoskeleton

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

cytoplasmic microtubule [inference]

axonemal microtubule

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
NAD+-protein ADP-ribosyltransferase activity	ISS	10508919
GTP binding	IBA ISS	10508919
GTPase activity	IEA
metal ion binding	IEA
phospholipid binding

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

NAD+-protein ADP-ribosyltransferase activity

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

catalytic activity, acting on a protein [inference]

NAD+-protein ADP-ribosyltransferase activity

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060340	ciliopathy	Alliance of Genome Resources
DOID:0110123	Bardet-Biedl syndrome 1	Alliance of Genome Resources
DOID:0110125	Bardet-Biedl syndrome 3	Alliance of Genome Resources
DOID:0110370	retinitis pigmentosa 55	Alliance of Genome Resources
DOID:1935	Bardet-Biedl syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 83** of 83 in total

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Species	Gene ID	Orthologous MAtrix
Athene cunicularia	113478310	ATHCN03531
Nannospalax galili	103741043	NANGA18594
Carlito syrichta	103263701	CARSF08257

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Acknowledgements