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ADP-ribosylation factor-like 6

Summary

Gene Symbol

Arl6

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

56297

PubChem

56297

Alliance of Genome Resources

MGI:1927136

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Cilium biogenesis/degradation
Cytoplasm
Cytoskeleton
GTP-binding
Magnesium
Metal-binding
Myristate
Protein transport
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3TUM2
O88848

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 16 in total

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GO Term	Evidence Code	PMID
retina layer formation	IMP	20333246 22139371
protein targeting to membrane
protein transport from ciliary membrane to plasma membrane	IMP	22139371
protein transport	IEA
protein localization to non-motile cilium	IDA	24939912

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

vesicle-mediated transport

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium

protein localization to non-motile cilium

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

protein-containing complex assembly [inference]

protein polymerization

organelle assembly [inference]

cilium assembly

cell projection organization

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization

membrane organization [inference]

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

retina layer formation

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium

protein localization to non-motile cilium

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

intracellular transport [inference]

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

organic substance transport [inference]

protein transport

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

nitrogen compound transport [inference]

protein transport

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium

protein localization to non-motile cilium

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport

intracellular protein transport

protein transport within lipid bilayer [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

protein localization to membrane [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane [inference]

establishment of protein localization to plasma membrane [inference]

protein transport from ciliary membrane to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
cilium	ISO
microtubule cytoskeleton	ISO
membrane coat
plasma membrane	IEA
cell projection	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

membrane coat

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

cell projection

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

microtubule cytoskeleton

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

cytoplasmic microtubule [inference]

axonemal microtubule

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
NAD+-protein ADP-ribosyltransferase activity	ISS	10508919
GTP binding	IBA ISS	10508919
GTPase activity	IEA
metal ion binding	IEA
phospholipid binding

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

NAD+-protein ADP-ribosyltransferase activity

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

catalytic activity, acting on a protein [inference]

NAD+-protein ADP-ribosyltransferase activity

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060340	ciliopathy	Alliance of Genome Resources
DOID:0110123	Bardet-Biedl syndrome 1	Alliance of Genome Resources
DOID:0110125	Bardet-Biedl syndrome 3	Alliance of Genome Resources
DOID:0110370	retinitis pigmentosa 55	Alliance of Genome Resources
DOID:1935	Bardet-Biedl syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Gadus morhua	115559075		GADMO11626
Oreochromis niloticus	100696267		ORENI34518
Sparus aurata	115580095		SPAAU24372
Xenopus tropicalis	100170493	Xenbase:XB-GENE-940504
Chrysemys picta bellii	101943808		CHRPI32119
Crocodylus porosus	109305655		CROPO02985
Pseudonaja textilis	113436355		PSETE07455
Anas platyrhynchos platyrhynchos	101804082		ANAPP04791
Serinus canaria	103818373		SERCA13872
Ornithorhynchus anatinus	100089849		ORNAN09287

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Acknowledgements