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Guidelines

MIRAGE

serine protease 3

Summary

Gene Symbol

PRSS3

Organism

Homo sapiens (human)

External Links

NCBI Gene

5646

PubChem

5646

Alliance of Genome Resources

HGNC:9486

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Digestion
Disulfide bond
Metal-binding
Reference proteome
Secreted
Serine protease
Signal
Sulfation
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P35030	Brain trypsinogen Mesotrypsin Mesotrypsinogen Serine protease 3 Serine protease 4 Trypsin III Trypsin IV
Q7Z5F4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
proteolysis	NAS	8294000
proteolysis	IDA	11827488 6698368
proteolysis	IBA
digestion	TAS	14507909 6698368
antimicrobial humoral response	TAS

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

cellular process [inference]

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

endothelial cell migration

multicellular organismal process [inference]

digestion

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

antimicrobial humoral response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

antimicrobial humoral response

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

antimicrobial humoral response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

antimicrobial humoral response

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	6698368
extracellular space	IBA
tertiary granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

tertiary granule lumen

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IDA	11827488 14507909 25301953 6698368
serine-type endopeptidase activity	IBA
calcium ion binding	IDA	11827488 6698368
protein binding	IPI	14507909 6698368
serine-type peptidase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

trypsin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Ortholog

Displaying entries **1 - 10** of 22 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	207	Xenbase:XB-GENE-484953
Xenopus tropicalis	5644	Xenbase:XB-GENE-5776262
Xenopus tropicalis	5645	Xenbase:XB-GENE-5776262
Xenopus tropicalis	5646	Xenbase:XB-GENE-484953
Xenopus tropicalis	11651	Xenbase:XB-GENE-484953
Xenopus tropicalis	24185	Xenbase:XB-GENE-484953
Xenopus tropicalis	399170	Xenbase:XB-GENE-484953
Pan troglodytes	747006		PANTR43829
Monodelphis domestica	100010619		MONDO33447
Monodelphis domestica	100010951		MONDO33495

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Last updated: April 7, 2025