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solute carrier family 22 (organic cation transporter), member 21

Summary

Gene Symbol

Slc22a21

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

56517

PubChem

56517

Alliance of Genome Resources

MGI:1929481

Annotation

Keyword

ATP-binding
Glycoprotein
Ion transport
Peroxisome
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A2RSK7
Q9WTN6	Organic cation/carnitine transporter 3 Solute carrier family 22 member 9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
response to tumor necrosis factor	ISO
carnitine transmembrane transport	IEA
monoatomic ion transport	IEA
positive regulation of intestinal epithelial structure maintenance	ISO
response to symbiotic bacterium	ISO

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

carnitine transmembrane transport

(R)-carnitine transmembrane transport

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

transmembrane transport [inference]

carnitine transmembrane transport

(R)-carnitine transmembrane transport

organic substance transport [inference]

organic cation transport [inference]

carnitine transport

(R)-carnitine transport

(R)-carnitine transmembrane transport

carnitine transmembrane transport

(R)-carnitine transmembrane transport

sodium-dependent organic cation transport

quaternary ammonium group transport

amino-acid betaine transport [inference]

carnitine transport

(R)-carnitine transport

(R)-carnitine transmembrane transport

carnitine transmembrane transport

(R)-carnitine transmembrane transport

modified amino acid transport [inference]

amino-acid betaine transport [inference]

carnitine transport

(R)-carnitine transport

(R)-carnitine transmembrane transport

carnitine transmembrane transport

(R)-carnitine transmembrane transport

nitrogen compound transport [inference]

quaternary ammonium group transport

amino-acid betaine transport [inference]

carnitine transport

(R)-carnitine transport

(R)-carnitine transmembrane transport

carnitine transmembrane transport

(R)-carnitine transmembrane transport

modified amino acid transport [inference]

amino-acid betaine transport [inference]

carnitine transport

(R)-carnitine transport

(R)-carnitine transmembrane transport

carnitine transmembrane transport

(R)-carnitine transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal epithelial structure maintenance

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal epithelial structure maintenance

regulation of intestinal epithelial structure maintenance [inference]

positive regulation of intestinal epithelial structure maintenance

positive regulation of multicellular organismal process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal epithelial structure maintenance

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
basal plasma membrane	ISO
apical plasma membrane	ISO
endoplasmic reticulum	ISO
peroxisome	IDA	12535646
cytoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
quaternary ammonium group transmembrane transporter activity	IBA ISO
ATP binding	IEA
organic cation transmembrane transporter activity
amino-acid betaine transmembrane transporter activity	ISO
PDZ domain binding	ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic cation transmembrane transporter activity

quaternary ammonium group transmembrane transporter activity

amino-acid betaine transmembrane transporter activity

carnitine transmembrane transporter activity

(R)-carnitine transmembrane transporter activity

modified amino acid transmembrane transporter activity [inference]

amino-acid betaine transmembrane transporter activity

carnitine transmembrane transporter activity

(R)-carnitine transmembrane transporter activity

binding [inference]

protein binding [inference]

protein domain specific binding [inference]

PDZ domain binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0050908	myelodysplastic syndrome	Alliance of Genome Resources
DOID:14365	systemic primary carnitine deficiency disease	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources
DOID:655	inherited metabolic disorder	Alliance of Genome Resources
DOID:8778	Crohn's disease	Alliance of Genome Resources