GlyCosmos Portal

kallikrein related peptidase 6

Summary

Gene Symbol

KLK6

Organism

Homo sapiens (human)

External Links

NCBI Gene

5653

PubChem

5653

Alliance of Genome Resources

HGNC:6367

Annotation

Keyword

3D-structure
Alternative splicing
Autocatalytic cleavage
Cleavage on pair of basic residues
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Microsome
Mitochondrion
Nucleus
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92876	Neurosin Protease M SP59 Serine protease 18 Serine protease 9 Zyme

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
central nervous system development	NAS	12589961
response to wounding	NAS	12016211
regulation of neuron projection development	IEA
protein autoprocessing	NAS	12878203
collagen catabolic process	NAS	12878203

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

amyloid precursor protein metabolic process

protein maturation

protein processing [inference]

protein autoprocessing

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

hormone metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

amyloid precursor protein metabolic process

protein maturation

protein processing [inference]

protein autoprocessing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

amyloid precursor protein metabolic process

protein maturation

protein processing [inference]

protein autoprocessing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

amyloid precursor protein metabolic process

protein maturation

protein processing [inference]

protein autoprocessing

cellular process [inference]

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

tissue regeneration

system development [inference]

central nervous system development

growth [inference]

developmental growth [inference]

tissue regeneration

response to stimulus [inference]

response to stress [inference]

response to wounding

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cornified envelope	IEA
extracellular region	IDA	11668196
extracellular space	IBA
extracellular space	HDA	16502470
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane [inference]

cornified envelope

organelle membrane [inference]

nuclear membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular non-membrane-bounded organelle [inference]

nucleolus

intercellular bridge

Displaying **all 4** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	NAS	12878203
serine-type endopeptidase activity	IDA	16885167
serine-type endopeptidase activity	IBA
protein binding	IPI	12709365 12878203 32814053

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

trypsin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:12217	Lewy body dementia	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:3213	demyelinating disease	Alliance of Genome Resources
DOID:4752	multiple system atrophy	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 66 in total

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Species	Gene ID	Orthologous MAtrix
Equus caballus	100146510	HORSE01424
Pongo abelii	100435375	PONAB14667
Cricetulus griseus	100753252	CRIGR20276
Otolemur garnettii	100953122	OTOGA00571
Pan troglodytes	101058031	PANTR19064
Felis catus	101088379	FELCA32951
Ovis aries	101113520	SHEEP05727
Gorilla gorilla gorilla	101146873	GORGO15272
Tursiops truncatus	101334266	TURTR01947
Dasypus novemcinctus	101420997	DASNO21527

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements