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Guidelines

MIRAGE

spire type actin nucleation factor 1

Summary

Gene Symbol

SPIRE1

Organism

Homo sapiens (human)

External Links

NCBI Gene

56907

PubChem

56907

Alliance of Genome Resources

HGNC:30622

JoGo

SPIRE1

TogoVar

SPIRE1

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Cell membrane
Coiled coil
Cytoplasmic vesicle
Cytoskeleton
Host-virus interaction
Innate immunity
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q08AE8
J3KNG6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

1

2

3

4

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GO Term	Evidence Code	PMID
protein transport	IEA
vesicle-mediated transport	ISS
actin cytoskeleton organization	IMP	21620703
actin filament polymerization
cleavage furrow formation	ISS

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

vesicle-mediated transport

Golgi vesicle transport

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

meiotic cytokinesis [inference]

polar body extrusion after meiotic divisions

cytokinetic process [inference]

cleavage furrow formation

spindle localization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

meiotic cell cycle process [inference]

meiotic cytokinesis [inference]

polar body extrusion after meiotic divisions

establishment of meiotic spindle localization

cellular process involved in reproduction in multicellular organism [inference]

polar body extrusion after meiotic divisions

actin filament-based process [inference]

actin cytoskeleton organization

cellular localization [inference]

intracellular transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

actin cytoskeleton organization

cellular component assembly [inference]

actin filament bundle assembly [inference]

parallel actin filament bundle assembly [inference]

formin-nucleated actin cable assembly

protein-containing complex assembly [inference]

protein polymerization [inference]

actin filament polymerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

actin filament polymerization

membrane organization [inference]

membrane invagination [inference]

plasma membrane invagination [inference]

cleavage furrow formation

supramolecular fiber organization [inference]

actin filament organization [inference]

actin polymerization or depolymerization [inference]

actin filament polymerization

actin filament bundle organization [inference]

actin filament bundle assembly [inference]

parallel actin filament bundle assembly [inference]

formin-nucleated actin cable assembly

formin-nucleated actin cable organization [inference]

formin-nucleated actin cable assembly

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

polar body extrusion after meiotic divisions

meiotic cell cycle process [inference]

meiotic cytokinesis [inference]

polar body extrusion after meiotic divisions

establishment of meiotic spindle localization

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

Golgi vesicle transport

intracellular transport

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport

establishment of spindle localization [inference]

establishment of meiotic spindle localization

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

organelle localization [inference]

spindle localization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of meiotic spindle localization

cellular localization [inference]

intracellular transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of developmental process [inference]

positive regulation of mitochondrial fission

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of mitochondrial fission [inference]

positive regulation of mitochondrial fission

positive regulation of developmental process [inference]

positive regulation of mitochondrial fission

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

regulation of mitochondrion organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

regulation of mitochondrial fission [inference]

positive regulation of mitochondrial fission

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair

regulation of double-strand break repair [inference]

positive regulation of double-strand break repair

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
mitochondrial outer membrane	IDA	26305500
cytosol	IDA
cytoskeleton	IEA
plasma membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

cytoplasm [inference]

cell cortex

cytosol

membrane [inference]

plasma membrane

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

plasma membrane region [inference]

cleavage furrow

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

perinuclear region of cytoplasm

Displaying **all 3** entries
GO Term	Evidence Code	PMID
actin binding	IEA
protein binding	IPI	32296183 32814053
microtubule binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

tubulin binding [inference]

microtubule binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

spire

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
Golgi vesicle transport
actin binding
actin filament network formation
actin filament organization
actin filament polymerization
actin nucleation
cleavage furrow formation
establishment of meiotic spindle localization
polar body extrusion after meiotic divisions

Displaying **all 3** entries
InterPro
KIND domain
Protein Spire
Zinc finger, FYVE/PHD-type

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026