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signal peptide peptidase like 2B

Summary

Gene Symbol

SPPL2B

Organism

Homo sapiens (human)

External Links

NCBI Gene

56928

PubChem

56928

Alliance of Genome Resources

HGNC:30627

Annotation

Keyword

Alternative splicing
Cell membrane
Endosome
Glycoprotein
Golgi apparatus
Lysosome
Protease
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TCT7	Intramembrane protease 4 Presenilin homologous protein 4 Presenilin-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane protein proteolysis	IBA IDA	2313285
membrane protein intracellular domain proteolysis	IDA IMP	16829951 16829952 19114711 22194595
regulation of immune response	IMP	16829952
regulation of tumor necrosis factor-mediated signaling pathway	TAS
membrane protein ectodomain proteolysis	IDA	16829951 17965014

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of immune response

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
Golgi-associated vesicle membrane	IBA IDA	17965014
membrane	IDA	2313285
cytoplasmic side of endoplasmic reticulum membrane	IBA IDA	15385547
plasma membrane	IDA TAS	16829952 19114711 21896273
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

microtubule organizing center [inference]

centrosome

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	17965014 2313285 32814053
aspartic endopeptidase activity, intramembrane cleaving	IBA IDA IMP TAS	16873890 19114711 22194595 2313285
protein homodimerization activity	IDA	15385547 15998642 16873890

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Peptidase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
aspartic endopeptidase activity, intramembrane cleaving
hydrolase activity
membrane protein proteolysis
signal peptide processing

Displaying **all 2** entries
InterPro
Peptidase A22B, signal peptide peptidase
Presenilin/signal peptide peptidase

Ortholog

Displaying entries **11 - 20** of 68 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Ornithorhynchus anatinus	100075206		ORNAN28485
Pongo abelii	100452050	9601_0:0048fe	PONAB14831
Ailuropoda melanoleuca	100465935		AILME05897
Sus scrofa	100515648		PIGXX18896
Meleagris gallopavo	100550519		MELGA09397
Loxodonta africana	100658259		LOXAF01892
Oreochromis niloticus	100696726		ORENI27578
Cavia porcellus	100719910		CAVPO25496
Cricetulus griseus	100760584		CRIGR10276
Sarcophilus harrisii	100919918		SARHA02150