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Guidelines

MIRAGE

dihydrouridine synthase 3 like

Summary

Gene Symbol

DUS3L

Organism

Homo sapiens (human)

External Links

NCBI Gene

56931

PubChem

56931

Alliance of Genome Resources

HGNC:26920

Annotation

Keyword

Acetylation
Alternative splicing
FMN
Isopeptide bond
NAD
NADP
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Ubl conjugation
Zinc-finger
mRNA processing
tRNA processing

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q96G46	mRNA-dihydrouridine synthase DUS3L tRNA-dihydrouridine synthase 3-like
B2RDV7	tRNA-dihydrouridine synthase 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
tRNA dihydrouridine synthesis	IDA	34556860
tRNA dihydrouridine synthesis	IMP	34798057
mRNA processing	IEA
regulation of translation	IDA	34556860

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

RNA modification [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

RNA modification [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

RNA modification [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

RNA modification [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

RNA modification [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

RNA modification [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

RNA modification [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

RNA modification [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

RNA modification [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

RNA modification [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA dihydrouridine synthesis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22681889
protein binding	IPI	32814053
zinc ion binding	IEA
tRNA dihydrouridine synthase activity	IBA
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [inference]

RNA dihydrouridine synthase activity [inference]

tRNA dihydrouridine synthase activity

tRNA-dihydrouridine47 synthase activity

mRNA dihydrouridine synthase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

tRNA dihydrouridine synthase activity

tRNA-dihydrouridine47 synthase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tRNA-dihydrouridine(47) synthase (NAD(P)(+))

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
flavin adenine dinucleotide binding
metal ion binding
oxidoreductase activity
tRNA dihydrouridine synthase activity
tRNA dihydrouridine synthesis
tRNA processing

Displaying **all 4** entries
InterPro
Aldolase-type TIM barrel
DUS-like, FMN-binding domain
Zinc finger, CCCH-type
tRNA-dihydrouridine synthase, conserved site

Ortholog

Displaying entries **1 - 10** of 68 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	56931	Xenbase:XB-GENE-943237
Mus musculus	224907		MOUSE20291
Rattus norvegicus	301122		RATNO43716
Danio rerio	393647		DANRE15658
Bos taurus	508812		BOVIN32835
Macaca mulatta	719524		MACMU20571
Pan troglodytes	739498		PANTR16885
Monodelphis domestica	100025142		MONDO19414
Ciona intestinalis	100169986		CIOIN05777
Salmo salar	100195410		SALSA96493

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Last updated: December 8, 2025