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aldo-keto reductase family 1 member B10

Summary

Gene Symbol

AKR1B10

Aliases

AKR1B12
ALDRLn
ARL-1
ARL1
HIS
HSI
aldo-keto reductase family 1, member B11 (aldose reductase-like)
aldose reductase-like 1
aldose reductase-like peptide
aldose reductase-related protein
small intestine reductase

Organism

Homo sapiens (human)

External Links

NCBI Gene

57016

HGNC

382

KEGG Gene ID

hsa:57016

PubChem

57016

Alliance of Genome Resources

HGNC:382

Annotation

Keyword

3D-structure
Acetylation
Lipid metabolism
Lysosome
NADP
Oxidoreductase
Reference proteome
Secreted

Proteins

Displaying 1 entry
UniProt	Protein Name
O60218	ARL-1 Aldose reductase-like Aldose reductase-related protein Small intestine reductase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cellular detoxification of aldehyde	IDA	19013440 19563777
farnesol catabolic process	IDA	21187079
retinoid metabolic process	IDA TAS	12732097
doxorubicin metabolic process	IMP	20837989
daunorubicin metabolic process	IMP	20837989

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

primary alcohol catabolic process [inference]

farnesol catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

primary alcohol catabolic process [inference]

farnesol catabolic process

secondary metabolic process [inference]

polyketide metabolic process [inference]

hormone metabolic process [inference]

retinol metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

sesquiterpenoid metabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

farnesol metabolic process [inference]

farnesol catabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

polyprenol metabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

farnesol metabolic process [inference]

farnesol catabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

sesquiterpenoid metabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

farnesol metabolic process [inference]

farnesol catabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

polyprenol metabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

farnesol metabolic process [inference]

farnesol catabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

farnesol metabolic process [inference]

farnesol catabolic process

primary alcohol metabolic process [inference]

farnesol metabolic process [inference]

farnesol catabolic process

primary alcohol catabolic process [inference]

farnesol catabolic process

alcohol catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

primary alcohol catabolic process [inference]

farnesol catabolic process

tertiary alcohol metabolic process [inference]

doxorubicin metabolic process

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

primary alcohol catabolic process [inference]

farnesol catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

sesquiterpenoid metabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

farnesol metabolic process [inference]

farnesol catabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

polyprenol metabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

farnesol metabolic process [inference]

farnesol catabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

polyketide metabolic process [inference]

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

olefinic compound metabolic process [inference]

retinol metabolic process

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

glycoside metabolic process [inference]

aminoglycoside antibiotic metabolic process [inference]

daunorubicin metabolic process

doxorubicin metabolic process

organic cyclic compound metabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

primary alcohol catabolic process [inference]

farnesol catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

farnesol metabolic process [inference]

farnesol catabolic process

primary alcohol metabolic process [inference]

farnesol metabolic process [inference]

farnesol catabolic process

primary alcohol catabolic process [inference]

farnesol catabolic process

alcohol catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

primary alcohol catabolic process [inference]

farnesol catabolic process

tertiary alcohol metabolic process [inference]

doxorubicin metabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

primary alcohol catabolic process [inference]

farnesol catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

sesquiterpenoid metabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

farnesol metabolic process [inference]

farnesol catabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

polyprenol metabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

farnesol metabolic process [inference]

farnesol catabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process [inference]

farnesol catabolic process

terpenoid catabolic process [inference]

sesquiterpenoid catabolic process [inference]

farnesol catabolic process

cellular detoxification [inference]

cellular detoxification of aldehyde

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

detoxification [inference]

cellular detoxification [inference]

cellular detoxification of aldehyde

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytosol	IBA TAS
extracellular region	IDA	21585341
mitochondrion	IBA
lysosome	IDA	21585341

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
alditol:NADP+ 1-oxidoreductase activity	IBA
retinal dehydrogenase activity	IDA	21851338
aldo-keto reductase (NADP) activity		9565553
allyl-alcohol dehydrogenase activity	IEA
indanol dehydrogenase activity	IDA	20837989

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

aldo-keto reductase (NADP) activity

alcohol dehydrogenase (NADP+) activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

retinal dehydrogenase activity

geranylgeranyl reductase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000198074

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00011

Name

aldehyde reductase [EC:1.1.1.21]

References

2498333

Rhea

RHEA:25033

all-trans-retinol + NADP⁺

H⁺ + all-trans-retinal + NADPH

Enzyme

1.1.1.300

PMID

RHEA:12168

allyl alcohol + NADP⁺

acrolein + H⁺ + NADPH

Enzyme

1.1.1.54

PMID

21169366

Disease

Disease Ontology

Displaying entries **1 - 10** of **117** in total

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DO ID	Disease Name	Source
DOID:0050589	inflammatory bowel disease	DisGeNET
DOID:0050742	nicotine dependence	DisGeNET
DOID:0050819	obsolete Matthew-Wood syndrome	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060262	gallbladder disease	DisGeNET
DOID:0060319	cardiac arrest	DisGeNET
DOID:0060490	Schimke immuno-osseous dysplasia	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0110734	neurodegeneration with brain iron accumulation	DisGeNET
DOID:0110735	neurodegeneration with brain iron accumulation 2a	DisGeNET

Ortholog

Displaying entries **1 - 10** of 42 in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	175047	WB:WBGene00012722
Caenorhabditis elegans	180997	WB:WBGene00015565
Drosophila melanogaster	35586	FB:FBgn0033101
Drosophila melanogaster	38462	FB:FBgn0035476
Drosophila melanogaster	38463	FB:FBgn0027552
Drosophila melanogaster	39304	FB:FBgn0086254
Drosophila melanogaster	39305	FB:FBgn0036183
Drosophila melanogaster	39424	FB:FBgn0036290
Danio rerio	553452	ZFIN:ZDB-GENE-041210-132
Xenopus tropicalis	496546	Xenbase:XB-GENE-5821742

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements