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ADAM metallopeptidase domain 17

Summary

Gene Symbol

Adam17

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

57027

PubChem

57027

Alliance of Genome Resources

RGD:620404

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Notch signaling pathway
Phosphoprotein
Reference proteome
SH3-binding
Signal
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Z1K9	TNF-alpha convertase TNF-alpha-converting enzyme

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 88 in total

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GO Term	Evidence Code	PMID
response to hypoxia	ISO
response to hypoxia	IEA
germinal center formation	ISO
production of molecular mediator involved in inflammatory response	ISO
proteolysis	ISS

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

germinal center formation

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

B cell activation [inference]

B cell differentiation

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

B cell activation [inference]

B cell differentiation

cell adhesion

cell adhesion mediated by integrin

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

Notch signaling pathway

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

T cell differentiation [inference]

T cell differentiation in thymus

cell motility

cell migration [inference]

wound healing, spreading of cells [inference]

wound healing, spreading of epidermal cells

cellular response to stimulus [inference]

cellular response to lipoprotein particle stimulus [inference]

cellular response to high density lipoprotein particle stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

commissural neuron axon guidance

export from cell [inference]

secretion by cell [inference]

signal release

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

B cell activation [inference]

B cell differentiation

production of molecular mediator involved in inflammatory response

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure formation involved in morphogenesis [inference]

germinal center formation

anatomical structure development [inference]

animal organ development [inference]

hematopoietic or lymphoid organ development [inference]

spleen development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

T cell differentiation [inference]

T cell differentiation in thymus

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to hypobaric hypoxia

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

germinal center formation

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to extracellular stimulus [inference]

response to nutrient levels

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to hypobaric hypoxia

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

response to activity [inference]

response to muscle activity

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to antineoplastic agent

response to oxygen-containing compound [inference]

response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to lipoprotein particle stimulus [inference]

cellular response to high density lipoprotein particle stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

signal release

export from cell [inference]

secretion by cell [inference]

signal release

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte migration [inference]

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of T cell migration [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of mast cell apoptotic process

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

regulation of tumor necrosis factor-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of signaling receptor activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte migration [inference]

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of T cell migration [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of neuron migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell growth

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

regulation of tumor necrosis factor-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of signaling receptor activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of axon regeneration

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

regulation of tumor necrosis factor-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration

regulation of response to wounding [inference]

regulation of axon regeneration

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of developmental process [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

Notch signaling pathway

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

regulation of tumor necrosis factor-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of signaling receptor activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

regulation of vascular endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of myeloid cell apoptotic process [inference]

regulation of mast cell apoptotic process

regulation of leukocyte apoptotic process [inference]

regulation of mast cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell growth

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular component organization

regulation of cell growth [inference]

positive regulation of cell growth

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle process [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of lymphocyte migration [inference]

regulation of lymphocyte chemotaxis [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of T cell migration [inference]

regulation of T cell chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of neuron migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of lymphocyte chemotaxis [inference]

positive regulation of T cell chemotaxis

positive regulation of T cell migration [inference]

positive regulation of T cell chemotaxis

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of blood vessel endothelial cell migration

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

regulation of protein tyrosine kinase activity [inference]

regulation of epidermal growth factor-activated receptor activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein tyrosine kinase activity [inference]

positive regulation of epidermal growth factor-activated receptor activity

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISO
cytosol	ISO
cytosol	IEA
plasma membrane	ISO
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

ruffle membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

anchoring junction [inference]

cell-cell junction

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

ruffle membrane

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

apical part of cell

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	ISS
endopeptidase activity	ISO
metalloendopeptidase activity	ISS
metalloendopeptidase activity	ISO
metalloendopeptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metallopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallodipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metallopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallodipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

Notch binding

cytokine receptor binding [inference]

interleukin-6 receptor binding

integrin binding

growth factor receptor binding [inference]

interleukin-6 receptor binding

protein domain specific binding [inference]

cytokine binding

tumor necrosis factor binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

disintegrin and metalloproteinase domain-containing protein

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
membrane protein ectodomain proteolysis
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 5** entries
InterPro
ADAM17, membrane-proximal domain
Disintegrin domain superfamily
Disintegrin domain
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
cell surface	PMID:21503882
apical part of cell	PMID:25232008

Ortholog

Displaying entries **21 - 30** of **111** in total

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Species	Gene ID	Orthologous MAtrix
Ailuropoda melanoleuca	100482770	AILME08715
Meleagris gallopavo	100549409	MELGA06340
Anolis carolinensis	100563907	ANOCA01136
Nomascus leucogenys	100605134	NOMLE16827
Loxodonta africana	100663807	LOXAF12695
Cricetulus griseus	100684971	CRIGR25084
Oreochromis niloticus	100700935	ORENI32052
Cavia porcellus	100732916	CAVPO20078
Sarcophilus harrisii	100926795	SARHA07902
Otolemur garnettii	100947870	OTOGA13952

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements