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MIRAGE

poly(ADP-ribose) polymerase family member 11

Summary

Gene Symbol

PARP11

Aliases

ARTD11

Organism

Homo sapiens (human)

External Links

NCBI Gene

57097

HGNC

1186

PubChem

57097

Alliance of Genome Resources

HGNC:1186

JoGo

PARP11

TogoVar

PARP11

Annotation

Keyword

3D-structure
ADP-ribosylation
Alternative splicing
Glycosyltransferase
NAD
Nuclear pore complex
Nucleotidyltransferase
Nucleus
Proteomics identification
Reference proteome
Spermatogenesis

Proteins

Displaying **all 2** entries
UniProt	Protein Name
G3V0I3
Q9NR21	ADP-ribosyltransferase diphtheria toxin-like 11 Poly [ADP-ribose] polymerase 11

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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2

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GO Term	Evidence Code	PMID
nuclear envelope organization	IEA
spermatogenesis	IEA
protein transport	IEA
cell differentiation	IEA
mRNA transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein auto-ADP-ribosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein auto-ADP-ribosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein auto-ADP-ribosylation

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein auto-ADP-ribosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein auto-ADP-ribosylation

cellular process [inference]

cellular developmental process [inference]

cell differentiation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

nuclear envelope organization

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

cellular developmental process [inference]

cell differentiation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

protein transport

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

mRNA transport

nitrogen compound transport [inference]

protein transport

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

mRNA transport

establishment of protein localization [inference]

protein transport

establishment of RNA localization [inference]

RNA transport [inference]

mRNA transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	IBA
nuclear envelope	IDA	25673562
nuclear pore	IEA
nucleoplasm	IDA
cytosol	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear pore

cellular anatomical entity [inference]

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
NAD+ ADP-ribosyltransferase activity	IDA	25673562
NAD+ ADP-ribosyltransferase activity	IBA
protein binding	IPI	32296183 32814053
nucleotidyltransferase activity	IEA
NAD+- protein-cysteine ADP-ribosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

NAD+ ADP-ribosyltransferase activity

NAD+-protein ADP-ribosyltransferase activity

NAD+-protein-glutamate ADP-ribosyltransferase activity

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity

catalytic activity, acting on a protein [inference]

NAD+-protein ADP-ribosyltransferase activity

NAD+-protein-glutamate ADP-ribosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

poly ADP-ribose polymerase

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
NAD+ ADP-ribosyltransferase activity
NAD+-protein ADP-ribosyltransferase activity
transferase activity

Displaying **all 3** entries
InterPro
Poly(ADP-ribose) polymerase, catalytic domain
WWE domain superfamily
WWE domain

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025