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CD177 molecule

Summary

Gene Symbol

CD177

Aliases

HNA2A
NB1
PRV1
polycythemia rubra vera 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

57126

HGNC

30072

KEGG Gene ID

hsa:57126

PubChem

57126

Alliance of Genome Resources

HGNC:30072

Annotation

Keyword

Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Direct protein sequencing
GPI-anchor
Innate immunity
Proteomics identification
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8N6Q3	Human neutrophil alloantigen 2a NB1 glycoprotein Polycythemia rubra vera protein 1
A0A087WVM2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
leukocyte cell-cell adhesion	IBA IMP	17580308
regulation of integrin-mediated signaling pathway	IBA IMP	28807980
innate immune response	IEA
protein localization to cell surface	IMP	17244676 18462208
neutrophil migration	IMP	28240246 28807980

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

leukocyte migration [inference]

cellular extravasation [inference]

neutrophil extravasation

myeloid leukocyte migration [inference]

granulocyte migration [inference]

neutrophil migration

neutrophil extravasation

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

cellular extravasation [inference]

neutrophil extravasation

myeloid leukocyte migration [inference]

granulocyte migration [inference]

neutrophil migration

neutrophil extravasation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

cell junction maintenance [inference]

cell-cell junction maintenance

cell-cell junction organization [inference]

cell-cell junction maintenance

cellular component maintenance [inference]

cell junction maintenance [inference]

cell-cell junction maintenance

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell surface

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

regulation of immune response [inference]

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

positive regulation of superoxide anion generation

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of integrin-mediated signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of endocytosis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of integrin-mediated signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

regulation of immune response [inference]

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of integrin-mediated signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

positive regulation of superoxide anion generation

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of cellular component organization [inference]

regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of endocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
extracellular exosome	HDA	23533145
specific granule membrane
tertiary granule membrane	IDA TAS	18462208

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

bounding membrane of organelle [inference]

secretory granule membrane

plasma membrane region [inference]

plasma membrane raft

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
integrin binding	IPI	21193407 28807980
calcium-dependent protein binding	IPI	17580308
protein binding	IPI	16189514 25416956 32296183
protease binding	IPI	17244676 28240246

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

protease binding

calcium-dependent protein binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000204936

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K06552

Name

CD177 antigen

References

Disease

Disease Ontology

Displaying entries **71 - 78** of 78 in total

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DO ID	Disease Name	Source
DOID:784	chronic kidney disease	DisGeNET
DOID:8432	polycythemia	DisGeNET DisGeNET DisGeNET DisGeNET
DOID:8469	influenza	DisGeNET
DOID:8552	chronic myeloid leukemia	DisGeNET
DOID:865	vasculitis	DisGeNET
DOID:8997	polycythemia vera	DisGeNET DisGeNET
DOID:9119	acute myeloid leukemia	DisGeNET
DOID:9256	colorectal cancer	DisGeNET

Ortholog

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Species	Gene ID	Orthologous MAtrix
Sarcophilus harrisii	105750074	SARHA16011
Cercocebus atys	105572284	CERAT43805
Macaca nemestrina	105463859	MACNE44981
Mandrillus leucophaeus	105552145	MANLE34167
Gorilla gorilla gorilla	101124597	GORGO15948
Pongo abelii	100453048	PONAB15804
Pongo abelii	100454150	PONAB15810
Canis lupus familiaris	612424	CANLF00991
Vulpes vulpes	112931553	VULVU27133
Ursus americanus	123777990	URSAM24532

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External Links

Annotation

KEGG BRITE Database

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Acknowledgements