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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
patched 1
Summary
- Gene Symbol
-
- PTCH1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Disease variant
- Glycoprotein
- Holoprosencephaly
- Isopeptide bond
- Phosphoprotein
- Receptor
- Reference proteome
- Transmembrane helix
- Tumor suppressor
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| Q13635 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| dorsal/ventral neural tube patterning | ||
| smoothened signaling pathway | ||
| negative regulation of osteoblast differentiation | ||
| cell proliferation involved in metanephros development | ||
| branching involved in ureteric bud morphogenesis |
GO Hierarchy
biological process
cellular process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
negative regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| postsynaptic membrane | ||
| Golgi apparatus | ||
| dendritic growth cone | ||
| midbody | ||
| endocytic vesicle membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| heparin binding | ||
| hedgehog family protein binding | ||
| cyclin binding | ||
| protein-containing complex binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- patched
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| hedgehog family protein binding |
| hedgehog receptor activity |
| smoothened binding |
| InterPro |
|---|
| Protein patched/dispatched |
| Sterol-sensing domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050860 | colorectal adenoma | |
| DOID:0050902 | medulloblastoma | |
| DOID:0070365 | nevoid basal cell carcinoma syndrome 1 | |
| DOID:0080016 | spina bifida | |
| DOID:0110876 | holoprosencephaly 7 | |
| DOID:10460 | nasopharyngitis | |
| DOID:10534 | stomach cancer | |
| DOID:1289 | neurodegenerative disease | |
| DOID:14330 | Parkinson's disease | |
| DOID:1793 | pancreatic cancer |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 19206 | MGI:105373 | MOUSE12236 | ||
| 30189 | ZFIN:ZDB-GENE-980526-196 | DANRE43029 | ||
| 35851 | FB:FBgn0003892 | |||
| 89830 | RGD:621425 | RATNO12423 | ||
| 173631 | WB:WBGene00004210 | |||
| 174274 | WB:WBGene00004208 | |||
| 398215 | Xenbase:XB-GENE-865776 | |||
| 465254 | 9598_0:0027bc | PANTR44381 | ||
| 484137 | CANLF00373 | |||
| 520994 | BOVIN34911 |
