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parathyroid hormone like hormone

Summary

Gene Symbol

PTHLH

Organism

Homo sapiens (human)

External Links

NCBI Gene

5744

PubChem

5744

Alliance of Genome Resources

HGNC:9607

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cleavage on pair of basic residues
Cytoplasm
Direct protein sequencing
Disease variant
Hormone
Nucleus
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P12272	Parathyroid hormone-like protein
Q53XY9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	TAS	10773581
cAMP metabolic process	TAS	2549037
bone mineralization	IEA
epidermis development	TAS	8058749
negative regulation of cell population proliferation	TAS	8058749

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

organic substance metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cyclic nucleotide metabolic process [inference]

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cAMP metabolic process

cyclic purine nucleotide metabolic process [inference]

cAMP metabolic process

cellular developmental process [inference]

cell development [inference]

osteoblast development

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

multi-multicellular organism process [inference]

female pregnancy

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

biomineral tissue development [inference]

bone mineralization

cell development [inference]

osteoblast development

system development [inference]

skeletal system development

cellular developmental process [inference]

cell development [inference]

osteoblast development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

signaling [inference]

cell-cell signaling

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of chondrocyte development

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of chondrocyte development

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

negative regulation of multicellular organismal process [inference]

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of chondrocyte differentiation

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

regulation of chondrocyte development [inference]

negative regulation of chondrocyte development

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of chondrocyte development

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of chondrocyte development

regulation of chondrocyte development [inference]

negative regulation of chondrocyte development

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of chondrocyte development

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

regulation of chondrocyte development [inference]

negative regulation of chondrocyte development

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cell population proliferation [inference]

regulation of cell differentiation [inference]

regulation of chondrocyte differentiation

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

regulation of chondrocyte development [inference]

negative regulation of chondrocyte development

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of chondrocyte development

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of chondrocyte development

regulation of chondrocyte development [inference]

negative regulation of chondrocyte development

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of chondrocyte development

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

regulation of chondrocyte development [inference]

negative regulation of chondrocyte development

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of chondrocyte development

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	IDA
extracellular region	TAS
nucleoplasm	IDA
extracellular space	TAS	8641188
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19674967
peptide hormone receptor binding	IBA IDA	19674967
hormone activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

hormone activity

hormone receptor binding [inference]

peptide hormone receptor binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

parathyroid hormone-like hormone a

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
bone mineralization
hormone activity

Displaying **all 2** entries
InterPro
Parathyroid hormone-related protein
Parathyroid hormone/parathyroid hormone-related protein

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080053	Albright's hereditary osteodystrophy	Alliance of Genome Resources
DOID:0110976	brachydactyly type E2	Alliance of Genome Resources
DOID:4480	achondroplasia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	19227		MGI:97800	MOUSE48726
Rattus norvegicus	24695		RGD:3441	RATNO31340
Bos taurus	286767			BOVIN30043
Sus scrofa	396951			PIGXX25950
Canis lupus familiaris	403987			CANLF10950
Pan troglodytes	473393	9598_0:003544		PANTR06219
Danio rerio	554221		ZFIN:ZDB-GENE-050119-9	DANRE33217
Felis catus	554222			FELCA16603
Macaca mulatta	710295			MACMU04931
Danio rerio	751101		ZFIN:ZDB-GENE-110411-206

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements