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Guidelines

MIRAGE

microtubule associated monooxygenase, calponin and LIM domain containing 3

Summary

Gene Symbol

MICAL3

Organism

Homo sapiens (human)

External Links

NCBI Gene

57553

PubChem

57553

Alliance of Genome Resources

HGNC:24694

Annotation

Keyword

3D-structure
Actin-binding
Alternative splicing
Cell division
Cell projection
Coiled coil
Cytoskeleton
Exocytosis
FAD
LIM domain
Monooxygenase
NADP
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7RTP6	Molecule interacting with CasL protein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
exocytosis	IEA
cytoskeleton organization	IDA	24440334
actin filament depolymerization	ISS
actin filament depolymerization	IDA	24440334
cell division	IEA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

exocytosis

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

actin filament depolymerization

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

actin filament depolymerization

supramolecular fiber organization [inference]

actin filament organization [inference]

actin polymerization or depolymerization [inference]

actin filament depolymerization

export from cell [inference]

secretion by cell [inference]

exocytosis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis

secretion [inference]

secretion by cell [inference]

exocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	PMID
nucleus	IDA	24440334
nucleoplasm	IDA
spindle	IEA
cytosol	IDA
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

cytoplasm [inference]

cell cortex

cytosol

membrane [inference]

plasma membrane

cell projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

spindle

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
actin binding	ISS
actin binding	IDA	24440334
protein binding	IPI	27528609
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	ISS
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein-methionine sulfoxide oxidase mical3a

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
FAD binding
actin binding
metal ion binding
monooxygenase activity

Displaying **all 5** entries
InterPro
CH domain superfamily
Calponin homology domain
FAD-binding domain
FAD/NAD(P)-binding domain superfamily
Zinc finger, LIM-type

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025