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ubiquitin specific peptidase 28

Summary

Gene Symbol

USP28

Organism

Homo sapiens (human)

External Links

NCBI Gene

57646

PubChem

57646

Alliance of Genome Resources

HGNC:12625

JoGo

USP28

TogoVar

USP28

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
DNA repair
Isopeptide bond
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Thiol protease
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A8V8TLZ9	Deubiquitinating enzyme 28 Ubiquitin thioesterase 28 Ubiquitin-specific-processing protease 28
Q96RU2	Deubiquitinating enzyme 28 Ubiquitin thioesterase 28 Ubiquitin-specific-processing protease 28
B4E3L3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
DNA damage checkpoint signaling	IMP	18662541
DNA damage checkpoint signaling	IBA
DNA repair	IEA
cellular response to DNA damage stimulus	IDA	17873522
DNA damage response	IDA	17873522

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

protein deubiquitination involved in ubiquitin-dependent protein catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

protein deubiquitination involved in ubiquitin-dependent protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

protein deubiquitination involved in ubiquitin-dependent protein catabolic process

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

protein deubiquitination involved in ubiquitin-dependent protein catabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

protein deubiquitination involved in ubiquitin-dependent protein catabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

cell population proliferation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

cellular response to UV

cellular response to light stimulus [inference]

cellular response to UV

response to ionizing radiation

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling

regulation of biological quality [inference]

regulation of protein stability

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA	17558397
cytosol	IBA
nuclear body	IDA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cysteine-type deubiquitinase activity	TAS
cysteine-type deubiquitinase activity	IDA	16901786 17558397
cysteine-type deubiquitinase activity	IMP	16901786 17558397
cysteine-type deubiquitinase activity	IBA
protein binding	IPI	16901786 17558397 17873522 24623306

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity

cysteine-type deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity

cysteine-type deubiquitinase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ubiquitin carboxyl-terminal hydrolase

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
hydrolase activity
proteasome binding
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process

Displaying **all 5** entries
InterPro
Papain-like cysteine peptidase superfamily
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
UBA-like superfamily
Ubiquitin specific protease domain
Ubiquitin specific protease, conserved site