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ubiquitin specific peptidase 37

Summary

Gene Symbol

USP37

Organism

Homo sapiens (human)

External Links

NCBI Gene

57695

PubChem

57695

Alliance of Genome Resources

HGNC:20063

Annotation

Keyword

3D-structure
Alternative splicing
Chromosome
Mitosis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Thiol protease
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q86T82	Deubiquitinating enzyme 37 Ubiquitin thioesterase 37 Ubiquitin-specific-processing protease 37

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
G1/S transition of mitotic cell cycle	IDA	21596315
G1/S transition of mitotic cell cycle	IBA
regulation of DNA replication	IMP	27296872
proteolysis	IEA
protein deubiquitination	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

cellular process [inference]

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

cell cycle G1/S phase transition [inference]

G1/S transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

cell division

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

regulation of macromolecule metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication

regulation of biological quality [inference]

regulation of protein stability

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IDA
nucleus	IBA
nucleoplasm	TAS
chromosome	IEA
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cysteine-type endopeptidase activity	IDA	21596315
cysteine-type deubiquitinase activity	TAS
cysteine-type deubiquitinase activity	IDA	14715245 21596315
cysteine-type deubiquitinase activity	IBA
protein binding	IPI	21596315 27296872

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ubiquitin carboxyl-terminal hydrolase

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
cell cycle
cell division
hydrolase activity
proteolysis

Displaying **all 7** entries
InterPro
Papain-like cysteine peptidase superfamily
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain superfamily
Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain
Ubiquitin interacting motif
Ubiquitin specific protease domain
Ubiquitin specific protease, conserved site