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Annotation

Keyword

3D-structure
Alternative splicing
DNA repair
DNA-binding
Disease variant
Helicase
Nucleus
Phosphoprotein
Premature ovarian failure
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IYD8	ATP-dependent RNA helicase FANCM Fanconi anemia-associated polypeptide of 250 kDa Protein Hef ortholog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
interstrand cross-link repair	IBA IDA	20347429
replication fork processing	IMP	20347428
resolution of meiotic recombination intermediates	IMP	20347428
positive regulation of protein monoubiquitination	IMP	29231814
double-strand break repair via synthesis-dependent strand annealing	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular process [inference]

cell cycle process [inference]

meiotic cell cycle process [inference]

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA geometric change [inference]

DNA duplex unwinding

reproductive process [inference]

meiotic cell cycle process [inference]

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via synthesis-dependent strand annealing

interstrand cross-link repair

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein monoubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein monoubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

regulation of protein monoubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination [inference]

positive regulation of protein monoubiquitination

Displaying **all 5** entries
GO Term	Evidence Code	PMID
FANCM-MHF complex	IDA IPI	20347428 20347429
nucleoplasm	IDA TAS
chromatin	IDA	20347429
cytosol	TAS
Fanconi anaemia nuclear complex	IDA	20347428 20347429

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

nuclear protein-containing complex [inference]

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	17289582 20347429 23932590 25416956 32296183 32769987 33961781
chromatin binding	IDA	20347429
nuclease activity	IEA
ATP hydrolysis activity	IEA
3'-5' DNA helicase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

DNA helicase activity [inference]

RNA helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

catalytic activity, acting on RNA [inference]

RNA helicase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

DNA secondary structure binding [inference]

four-way junction DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity [inference]

DNA helicase activity [inference]

RNA helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

ATP-dependent activity, acting on RNA [inference]

RNA helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

helicase

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
DNA2/NAM7 helicase, helicase domain
DNA2/NAM7 helicase-like, C-terminal
P-loop containing nucleoside triphosphate hydrolase
Upf1-like, C-terminal helicase domain

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050865	tongue squamous cell carcinoma	Alliance of Genome Resources
DOID:0080872	primary ovarian insufficiency 15	Alliance of Genome Resources
DOID:0111916	spermatogenic failure 28	Alliance of Genome Resources
DOID:13636	Fanconi anemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 60 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	42543		FB:FBgn0038889
Mus musculus	104806		MGI:2442306	MOUSE08260
Rattus norvegicus	314172		RGD:1307897	RATNO35550
Pan troglodytes	452885	9598_0:003b61		PANTR08669
Canis lupus familiaris	480307			CANLF17879
Bos taurus	513626			BOVIN16829
Macaca mulatta	702513			MACMU42472
Saccharomyces cerevisiae S288C	854818		SGD:S000001441
Danio rerio	100006685		ZFIN:ZDB-GENE-090929-1
Equus caballus	100063761			HORSE16610

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements