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protein tyrosine phosphatase non-receptor type 2
Summary
- Gene Symbol
-
- PTPN2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Cytoplasm
- Endoplasmic reticulum
- Nucleus
- Phosphoprotein
- Protein phosphatase
- Proteomics identification
- Receptor
- Reference proteome
- S-nitrosylation
- Transmembrane helix
- Proteins
Gene Ontology (GO)
GO Hierarchy
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of insulin receptor signaling pathway
- regulation of hepatocyte growth factor receptor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of insulin receptor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of insulin receptor signaling pathway
- negative regulation of cell population proliferation
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of insulin receptor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of insulin receptor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of insulin receptor signaling pathway
- regulation of hepatocyte growth factor receptor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of insulin receptor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of insulin receptor signaling pathway
- regulation of hepatocyte growth factor receptor signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of insulin receptor signaling pathway
- negative regulation of cell population proliferation
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of type II interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- negative regulation of interleukin-6-mediated signaling pathway
- negative regulation of interleukin-2-mediated signaling pathway
- negative regulation of interleukin-4-mediated signaling pathway
- negative regulation of macrophage colony-stimulating factor signaling pathway
- negative regulation of insulin receptor signaling pathway
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
regulation of cytokine-mediated signaling pathway [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
negative regulation of signal transduction [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
regulation of intracellular signal transduction [inference]
negative regulation of signaling [inference]
negative regulation of signal transduction [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of signaling [inference]
negative regulation of signal transduction [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
negative regulation of cellular process [inference]
negative regulation of cell communication [inference]
negative regulation of signal transduction [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of response to stimulus [inference]
negative regulation of signal transduction [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
negative regulation of defense response [inference]
negative regulation of response to external stimulus [inference]
negative regulation of response to cytokine stimulus [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
negative regulation of developmental process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of signal transduction [inference]
regulation of cytokine-mediated signaling pathway [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
negative regulation of signal transduction [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
regulation of intracellular signal transduction [inference]
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
negative regulation of response to stimulus [inference]
negative regulation of signal transduction [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
negative regulation of defense response [inference]
negative regulation of response to external stimulus [inference]
negative regulation of response to cytokine stimulus [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
regulation of immune response [inference]
regulation of response to cytokine stimulus [inference]
regulation of cytokine-mediated signaling pathway [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
negative regulation of response to cytokine stimulus [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
regulation of response to stress [inference]
regulation of defense response [inference]
regulation of cellular response to stress [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
negative regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
regulation of cytokine-mediated signaling pathway [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
negative regulation of signal transduction [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
regulation of intracellular signal transduction [inference]
negative regulation of cell communication [inference]
negative regulation of signal transduction [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
negative regulation of cell communication [inference]
negative regulation of signal transduction [inference]
negative regulation of cytokine-mediated signaling pathway [inference]
negative regulation of cellular metabolic process [inference]
regulation of cell activation [inference]
regulation of cellular response to stress [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| nucleoplasm | ||
| endosome lumen | ||
| endoplasmic reticulum | ||
| endoplasmic reticulum-Golgi intermediate compartment |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| integrin binding | ||
| protein tyrosine phosphatase activity | ||
| non-membrane spanning protein tyrosine phosphatase activity | ||
| STAT family protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- protein tyrosine phosphatase
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- P: Inorganic ion transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| superoxide anion generation |
| superoxide-generating NADPH oxidase activator activity |
| InterPro |
|---|
| Tetratricopeptide repeat |
| Tetratricopeptide-like helical domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10155 | intestinal cancer | |
| DOID:10591 | pre-eclampsia |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 19255 | MGI:97806 | MOUSE23977 | ||
| 38160 | FB:FBgn0267487 | |||
| 117063 | RGD:620710 | RATNO14168 | ||
| 393438 | ZFIN:ZDB-GENE-040426-1196 | |||
| 431888 | Xenbase:XB-GENE-953566 | |||
| 446745 | Xenbase:XB-GENE-17341763 | |||
| 455504 | 9598_0:004991 | PANTR15804 | ||
| 490563 | CANLF17665 | |||
| 540888 | BOVIN19680 | |||
| 561613 | ZFIN:ZDB-GENE-030909-8 | DANRE16177 |
