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protein tyrosine phosphatase receptor type N2

Summary

Gene Symbol

PTPRN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5799

PubChem

5799

Alliance of Genome Resources

HGNC:9677

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasmic vesicle
Diabetes mellitus
Glycoprotein
Phospholipid metabolism
Phosphoprotein
Protein phosphatase
Proteomics identification
Receptor
Reference proteome
Signal
Synapse
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
E7EM83
Q92932	Islet cell autoantigen-related protein Phogrin
I6L9F8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
chromatin remodeling	IEA
protein dephosphorylation	TAS	8798755
lipid metabolic process	IEA
neurotransmitter secretion	ISS
insulin secretion involved in cellular response to glucose stimulus	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

primary metabolic process [inference]

lipid metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance metabolic process [inference]

lipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release from synapse [inference]

neurotransmitter secretion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

secretion by cell [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release from synapse [inference]

neurotransmitter secretion

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

signal release from synapse [inference]

neurotransmitter secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of localization in cell [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion [inference]

insulin secretion involved in cellular response to glucose stimulus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
secretory granule	IBA
secretory granule membrane	ISS
synaptic vesicle membrane	ISS
receptor complex	IDA	23382219

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane

ficolin-1-rich granule membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane

ficolin-1-rich granule membrane

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

Displaying **all 4** entries
GO Term	Evidence Code	PMID
non-membrane spanning protein tyrosine phosphatase activity	IEA
transmembrane receptor protein tyrosine phosphatase activity	TAS	8798755
protein tyrosine phosphatase activity, metal-dependent	IEA
histone H2AXY142 phosphatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

histone modifying activity [inference]

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aminopeptidase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
aminopeptidase activity
hydrolase activity
metal ion binding
metalloaminopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 2** entries
InterPro
Peptidase M18, domain 2
Peptidase M18

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:11716	prediabetes syndrome	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 21 in total

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Species	Gene ID	Orthologous MAtrix
Pan paniscus	100978473	PANPA37651
Papio anubis	101026166	PAPAN29476
Saimiri boliviensis boliviensis	101037465	SAIBB35581
Felis catus	101089683	FELCA05522
Gorilla gorilla gorilla	101125353	GORGO39717
Mustela putorius furo	101682161	MUSPF07681
Sus scrofa	102158899	PIGXX12191
Cercocebus atys	105591478	CERAT39760
Macaca mulatta	106997750	MACMU32645
Rhinolophus ferrumequinum	117018052	RHIFE12028