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pentraxin 3

Summary

Gene Symbol

PTX3

Organism

Homo sapiens (human)

External Links

NCBI Gene

5806

PubChem

5806

Alliance of Genome Resources

HGNC:9692

Annotation

Keyword

3D-structure
Coiled coil
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P26022	Pentaxin-related protein PTX3 Tumor necrosis factor alpha-induced protein 5 Tumor necrosis factor-inducible gene 14 protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
negative regulation of viral entry into host cell	IDA	23544079
negative regulation of glycoprotein metabolic process	IDA	23544079
negative regulation by host of viral glycoprotein metabolic process	IDA	23544079
negative regulation of exo-alpha-sialidase activity	IDA	23544079
positive regulation of phagocytosis	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

opsonization

immune response [inference]

innate immune response

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

reproductive process [inference]

ovulation cycle process [inference]

ovarian cumulus expansion

growth [inference]

developmental growth [inference]

ovarian cumulus expansion

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

modulation by host of viral process [inference]

negative regulation by host of viral process

negative regulation by host of viral glycoprotein metabolic process

modulation by host of viral molecular function [inference]

modulation by host of viral catalytic activity [inference]

modulation by host of viral exo-alpha-sialidase activity [inference]

negative regulation by host of viral exo-alpha-sialidase activity

modulation by host of viral glycoprotein metabolic process [inference]

negative regulation by host of viral glycoprotein metabolic process

modulation by host of symbiont catalytic activity [inference]

negative regulation by host of symbiont catalytic activity [inference]

negative regulation by host of viral exo-alpha-sialidase activity

response to other organism [inference]

response to fungus [inference]

response to yeast

defense response to other organism [inference]

innate immune response

rhythmic process [inference]

ovulation cycle process [inference]

ovarian cumulus expansion

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to fungus [inference]

response to yeast

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to fungus [inference]

response to yeast

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

negative regulation of viral entry into host cell

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process

negative regulation by host of viral glycoprotein metabolic process

negative regulation of viral process [inference]

negative regulation by host of viral glycoprotein metabolic process

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell

regulation of viral process [inference]

negative regulation of viral process [inference]

negative regulation by host of viral glycoprotein metabolic process

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

negative regulation of viral entry into host cell

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of exo-alpha-sialidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of exo-alpha-sialidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of exo-alpha-sialidase activity

regulation of exo-alpha-sialidase activity [inference]

negative regulation of exo-alpha-sialidase activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular matrix	IEA
specific granule lumen	TAS
tertiary granule lumen	TAS
extracellular region	TAS
extracellular space	IBA IDA	23544079

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

tertiary granule lumen

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19050261 19632990 20363749 21490156 22267482 22786770 28533443 29374201 35102342
complement component C1q complex binding	IBA IDA	23544079
(1->3)-beta-D-glucan binding	IEA
identical protein binding	IPI	20363749
virion binding	IDA	23544079

GO Hierarchy

molecular function

binding [inference]

protein binding

opsonin binding [inference]

complement component C1q complex binding

complement binding [inference]

complement component C1q complex binding

identical protein binding

carbohydrate binding [inference]

polysaccharide binding [inference]

(1->3)-beta-D-glucan binding

protein-containing complex binding [inference]

complement component C1q complex binding

virion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Pentraxin-related protein PTX3

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
complement component C1q complex binding
immune response
negative regulation by host of viral process

Displaying **all 3** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
Pentraxin-related protein PTX3
Pentraxin-related

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050073	invasive aspergillosis	Alliance of Genome Resources
DOID:0050153	pulmonary aspergilloma	Alliance of Genome Resources
DOID:1003	pelvic inflammatory disease	Alliance of Genome Resources
DOID:14115	toxic shock syndrome	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:1883	hepatitis C	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 97 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	19288		MGI:104641	MOUSE38770
Pan troglodytes	460807	9598_0:001352		PANTR32524
Bos taurus	541148			BOVIN15103
Danio rerio	566001		ZFIN:ZDB-GENE-081104-385
Rattus norvegicus	689388		RGD:1593476	RATNO25576
Macaca mulatta	704985			MACMU29945
Ovis aries	100034672			SHEEP01689
Xenopus laevis	100036916		Xenbase:XB-GENE-5920016
Ornithorhynchus anatinus	100081868			ORNAN11059
Oryctolagus cuniculus	100343665			RABIT04519

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OrthoDB (Group)

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Acknowledgements