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polypyrimidine tract binding protein 2

Summary

Gene Symbol

PTBP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

58155

PubChem

58155

Alliance of Genome Resources

HGNC:17662

JoGo

PTBP2

TogoVar

PTBP2

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Direct protein sequencing
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Repeat
mRNA splicing

Proteins

Displaying **all 5** entries
UniProt	Protein Name
B4DSU5	Neural polypyrimidine tract-binding protein
B4DSS8	Neural polypyrimidine tract-binding protein
A0A6Q8PFE6	Neural polypyrimidine tract-binding protein
Q9UKA9	Neural polypyrimidine tract-binding protein Neurally-enriched homolog of PTB PTB-like protein
A0A7I2RVZ4	Neural polypyrimidine tract-binding protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mRNA splice site recognition	IEA
negative regulation of RNA splicing	IDA	18335065
regulation of RNA splicing	IBA
regulation of neural precursor cell proliferation	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

mRNA splice site recognition

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

mRNA splice site recognition

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

mRNA splice site recognition

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

regulation of RNA splicing

negative regulation of RNA splicing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

regulation of RNA metabolic process [inference]

regulation of RNA splicing

negative regulation of RNA splicing

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

regulation of RNA splicing

negative regulation of RNA splicing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

regulation of RNA metabolic process [inference]

regulation of RNA splicing

negative regulation of RNA splicing

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

regulation of RNA splicing

negative regulation of RNA splicing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

regulation of RNA metabolic process [inference]

regulation of RNA splicing

negative regulation of RNA splicing

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

regulation of RNA metabolic process [inference]

regulation of RNA splicing

negative regulation of RNA splicing

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

regulation of RNA metabolic process [inference]

regulation of RNA splicing

negative regulation of RNA splicing

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

regulation of RNA splicing

negative regulation of RNA splicing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

regulation of cell population proliferation [inference]

regulation of neural precursor cell proliferation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of RNA splicing

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA splicing

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleus	IBA
spliceosomal complex	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

spliceosomal complex

ribonucleoprotein complex [inference]

spliceosomal complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
mRNA binding	IBA
protein binding	IPI	26871637 32296183 32814053

GO Hierarchy

molecular function

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

mRNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Polypyrimidine tract-binding protein

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
mRNA processing
regulation of RNA splicing

Displaying **all 5** entries
InterPro
HnRNP-L/PTB
Nucleotide-binding alpha-beta plait domain superfamily
PTBP1-like, RNA recognition motif 2
RNA recognition motif domain
RNA-binding domain superfamily