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aldehyde dehydrogenase 18 family member A1

Summary

Gene Symbol

ALDH18A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5832

PubChem

5832

Alliance of Genome Resources

HGNC:9722

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Disease variant
Hereditary spastic paraplegia
Intellectual disability
Kinase
Mitochondrion inner membrane
Multifunctional enzyme
NADP
Oxidoreductase
Proline biosynthesis
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P54886	Aldehyde dehydrogenase family 18 member A1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
citrulline biosynthetic process	IMP	11092761 26297558
proline biosynthetic process	IMP	11092761 26297558
L-proline biosynthetic process	IEA
phosphorylation	IEA
response to temperature stimulus	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

glutamate metabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

alpha-amino acid metabolic process [inference]

citrulline metabolic process [inference]

citrulline biosynthetic process

ornithine metabolic process [inference]

ornithine biosynthetic process

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

heterocycle biosynthetic process [inference]

L-proline biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

organic cyclic compound biosynthetic process [inference]

L-proline biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

alpha-amino acid metabolic process [inference]

citrulline metabolic process [inference]

citrulline biosynthetic process

ornithine metabolic process [inference]

ornithine biosynthetic process

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

heterocycle biosynthetic process [inference]

L-proline biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

L-proline biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

alpha-amino acid metabolic process [inference]

citrulline metabolic process [inference]

citrulline biosynthetic process

ornithine metabolic process [inference]

ornithine biosynthetic process

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

alpha-amino acid metabolic process [inference]

citrulline metabolic process [inference]

citrulline biosynthetic process

ornithine metabolic process [inference]

ornithine biosynthetic process

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

alpha-amino acid metabolic process [inference]

citrulline metabolic process [inference]

citrulline biosynthetic process

ornithine metabolic process [inference]

ornithine biosynthetic process

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

organic cyclic compound metabolic process [inference]

organic cyclic compound biosynthetic process [inference]

L-proline biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

alpha-amino acid metabolic process [inference]

citrulline metabolic process [inference]

citrulline biosynthetic process

ornithine metabolic process [inference]

ornithine biosynthetic process

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

organic cyclic compound biosynthetic process [inference]

L-proline biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

alpha-amino acid metabolic process [inference]

citrulline metabolic process [inference]

citrulline biosynthetic process

ornithine metabolic process [inference]

ornithine biosynthetic process

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

proline metabolic process [inference]

proline biosynthetic process

L-proline biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

ornithine biosynthetic process

glutamine family amino acid biosynthetic process [inference]

proline biosynthetic process

L-proline biosynthetic process

citrulline biosynthetic process

heterocycle biosynthetic process [inference]

L-proline biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

L-proline biosynthetic process

response to stimulus [inference]

response to abiotic stimulus [inference]

response to temperature stimulus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	TAS
mitochondrion	HTP IBA IDA	26297558 26320891 34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	25416956 32296183
glutamate-5-semialdehyde dehydrogenase activity	IBA IDA IMP	11092761 26297558
identical protein binding	IDA	26297558
glutamate 5-kinase activity	IDA IMP	11092761 26297558
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

glutamate-5-semialdehyde dehydrogenase activity

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

amino acid kinase activity [inference]

glutamate 5-kinase activity

phosphotransferase activity, carboxyl group as acceptor [inference]

glutamate 5-kinase activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Delta-1-pyrroline-5-carboxylate synthase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
ATP binding
L-proline biosynthetic process
amino acid biosynthetic process
glutamate 5-kinase activity
kinase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity
proline biosynthetic process

Displaying **all 7** entries
InterPro
Aldehyde dehydrogenase domain
Aldehyde dehydrogenase, C-terminal
Aldehyde dehydrogenase, N-terminal
Aldehyde/histidinol dehydrogenase
Aspartate/glutamate/uridylate kinase
GPR domain
Gamma-glutamyl phosphate reductase GPR, conserved site

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0070131	autosomal dominant cutis laxa 3	Alliance of Genome Resources
DOID:0070132	autosomal recessive cutis laxa type IIIA	Alliance of Genome Resources
DOID:0070143	autosomal recessive cutis laxa type III	Alliance of Genome Resources
DOID:0110824	hereditary spastic paraplegia 9A	Alliance of Genome Resources
DOID:0110825	hereditary spastic paraplegia 9B	Alliance of Genome Resources
DOID:1283	enterocele	Alliance of Genome Resources
DOID:2476	hereditary spastic paraplegia	Alliance of Genome Resources
DOID:83	cataract	Alliance of Genome Resources
DOID:9252	amino acid metabolic disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **102** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	40443		FB:FBgn0037146
Mus musculus	56454		MGI:1888908	MOUSE25691
Rattus norvegicus	361755		RGD:1311431	RATNO18575
Xenopus laevis	444469		Xenbase:XB-GENE-5765640
Pan troglodytes	450629	9598_0:002c30		PANTR01221
Canis lupus familiaris	477781			CANLF11328
Bos taurus	514759			BOVIN21244
Xenopus tropicalis	550060		Xenbase:XB-GENE-5765545
Danio rerio	557186		ZFIN:ZDB-GENE-030131-5602	DANRE04110
Macaca mulatta	703357			MACMU46460

GlyTouCan

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements